C₁₂H₉ClFNO₂S

Base Information

Chemical Name:C₁₂H₉ClFNO₂S
CAS No.:1415115-14-8
Molecular Formula:C₁₂H₉ClFNO₂S
Molecular Weight:285.726
Hs Code.:

C<sub>12</sub>H<sub>9</sub>ClFNO<sub>2</sub>S

Synonyms:C₁₂H₉ClFNO₂S

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Chemical Property of C₁₂H₉ClFNO₂S

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Technology Process of C₁₂H₉ClFNO₂S

There total 3 articles about C₁₂H₉ClFNO₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 637-87-6
1-Chloro-4-iodobenzene

: 1415115-02-4
2-pyridyl fluoroiodomethyl sulfone

: 1415115-14-8
C₁₂H₉ClFNO₂S

Guidance literature:: 2-pyridyl fluoroiodomethyl sulfone; With diethylzinc; In hexane; N,N-dimethyl-formamide; at -30 - -25 ℃; for 0.0833333h; Inert atmosphere;

With copper(l) iodide; In hexane; N,N-dimethyl-formamide; at -15 ℃; for 0.25h; Inert atmosphere;

1-Chloro-4-iodobenzene; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/ol3029737

Reference yield: 77.0%

: 637-87-6
1-Chloro-4-iodobenzene

: 1365765-67-8
2-fluoro-1-(4-methoxyphenyl)-2-(pyridin-2-ylsulfonyl)ethanone

: 1415115-14-8
C₁₂H₉ClFNO₂S

Guidance literature:: 1-Chloro-4-iodobenzene; 2-fluoro-1-(4-methoxyphenyl)-2-(pyridin-2-ylsulfonyl)ethanone; With copper(I) thiophene-2-carboxylate; sodium hydrogencarbonate; In dimethyl sulfoxide; at 80 ℃; for 20h;

With methanol; In dimethyl sulfoxide; at 80 ℃; for 1h;
DOI:10.1021/cs4000574

Reference yield:

: 1365765-53-2
2-((fluoromethyl)sulfonyl)pyridine

: 1415115-14-8
C₁₂H₉ClFNO₂S

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate; N-iodo-succinimide / N,N-dimethyl-formamide / 0.5 h / 5 °C / Inert atmosphere

2.1: diethylzinc / N,N-dimethyl-formamide; hexane / 0.08 h / -30 - -25 °C / Inert atmosphere

2.2: 0.25 h / -15 °C / Inert atmosphere

2.3: 8 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; potassium tert-butylate; diethylzinc; In hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol3029737