(R)-4-[(4-methylphenylsulfonyloxy)methyl]-2-(2-pyridyl)-4,5-dihydrooxazole

Base Information

Chemical Name:(R)-4-[(4-methylphenylsulfonyloxy)methyl]-2-(2-pyridyl)-4,5-dihydrooxazole
CAS No.:1620662-87-4
Molecular Formula:C₁₆H₁₆N₂O₄S
Molecular Weight:332.38
Hs Code.:

Synonyms:(R)-4-[(4-methylphenylsulfonyloxy)methyl]-2-(2-pyridyl)-4,5-dihydrooxazole

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Chemical Property of (R)-4-[(4-methylphenylsulfonyloxy)methyl]-2-(2-pyridyl)-4,5-dihydrooxazole

Chemical Property:

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Technology Process of (R)-4-[(4-methylphenylsulfonyloxy)methyl]-2-(2-pyridyl)-4,5-dihydrooxazole

There total 7 articles about (R)-4-[(4-methylphenylsulfonyloxy)methyl]-2-(2-pyridyl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1620662-85-2
(S)-4-(hydroxymethyl)-2-(2-pyridyl)-4,5-dihydrooxazole

: 98-59-9
p-toluenesulfonyl chloride

: 1620662-87-4
(R)-4-[(4-methylphenylsulfonyloxy)methyl]-2-(2-pyridyl)-4,5-dihydrooxazole

Guidance literature:: With potassium hydroxide; In dichloromethane; water; for 3h; Reflux;
DOI:10.1055/s-0033-1340044

Reference yield:

: 98-98-6
2-Picolinic acid

: 1620662-87-4
(R)-4-[(4-methylphenylsulfonyloxy)methyl]-2-(2-pyridyl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 7 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0.5 h / 0 °C

2: tetrahydrofuran / 2 h / 0 - 20 °C

3: 1H-imidazole / dichloromethane / 1 h / 20 °C

4: lithium borohydride / tetrahydrofuran / 3 h / 0 °C

5: p-toluenesulfonyl chloride; dmap; triethylamine / 1,2-dichloro-ethane / 16 h / Reflux

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

7: potassium hydroxide / dichloromethane; water / 3 h / Reflux

With 4-methyl-morpholine; 1H-imidazole; dmap; lithium borohydride; tetrabutyl ammonium fluoride; triethylamine; p-toluenesulfonyl chloride; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1055/s-0033-1340044

Reference yield:

: 1620662-86-3
N-[(R)-2-(tert-butyldimethylsilyloxy)-1-(hydroxymethyl)ethyl]picolinamide

: 1620662-87-4
(R)-4-[(4-methylphenylsulfonyloxy)methyl]-2-(2-pyridyl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1: p-toluenesulfonyl chloride; dmap; triethylamine / 1,2-dichloro-ethane / 16 h / Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3: potassium hydroxide / dichloromethane; water / 3 h / Reflux

With dmap; tetrabutyl ammonium fluoride; triethylamine; p-toluenesulfonyl chloride; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1055/s-0033-1340044