diphenylmethyl(1S,6R,7R)-3-bromomethyl-7-formamido-ceph-3-em-4-carboxylate-1-oxide

Base Information

Chemical Name:diphenylmethyl(1S,6R,7R)-3-bromomethyl-7-formamido-ceph-3-em-4-carboxylate-1-oxide
CAS No.:41804-10-8
Molecular Formula:C₂₂H₁₉BrN₂O₅S
Molecular Weight:503.373
Hs Code.:

Synonyms:diphenylmethyl(1S,6R,7R)-3-bromomethyl-7-formamido-ceph-3-em-4-carboxylate-1-oxide

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Chemical Property of diphenylmethyl(1S,6R,7R)-3-bromomethyl-7-formamido-ceph-3-em-4-carboxylate-1-oxide

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Technology Process of diphenylmethyl(1S,6R,7R)-3-bromomethyl-7-formamido-ceph-3-em-4-carboxylate-1-oxide

There total 3 articles about diphenylmethyl(1S,6R,7R)-3-bromomethyl-7-formamido-ceph-3-em-4-carboxylate-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 98376-12-6
diphenylmethyl(1S,6R,7R)-7-formamido-3-methylceph-3-em-4-carboxylate-1-oxide

: 41804-10-8
diphenylmethyl(1S,6R,7R)-3-bromomethyl-7-formamido-ceph-3-em-4-carboxylate-1-oxide

Guidance literature:: With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium acetate; acetic acid; In dichloromethane; water; at -10 ℃; for 0.666667h; Irradiation; pH=7;
DOI:10.1016/S0040-4020(01)96571-8

Reference yield:

: 33748-47-9
diphenylmethyl(6R,7R)-7-formamido-3-methylceph-3-em-4-carboxylate

: 41804-10-8
diphenylmethyl(1S,6R,7R)-3-bromomethyl-7-formamido-ceph-3-em-4-carboxylate-1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / peracetic acid / 1,2-dichloro-ethane / 0.5 h

2: 60 percent / NaOAc, HOAc, 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) / CH₂Cl₂; H₂O / 0.67 h / -10 °C / Irradiation; pH=7

With peracetic acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium acetate; acetic acid; In dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4020(01)96571-8

Reference yield:

: 49597-68-4
(6R,7R)-7-Amino-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester; hydrochloride

: 41804-10-8
diphenylmethyl(1S,6R,7R)-3-bromomethyl-7-formamido-ceph-3-em-4-carboxylate-1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / 1.) NaHCO₃; 2.) HCO₂H / 1.) CH₂Cl₂, H₂O, 30 min; 2.) reflux, 18 h

2: 94 percent / peracetic acid / 1,2-dichloro-ethane / 0.5 h

3: 60 percent / NaOAc, HOAc, 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) / CH₂Cl₂; H₂O / 0.67 h / -10 °C / Irradiation; pH=7

With peracetic acid; formic acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium acetate; sodium hydrogencarbonate; acetic acid; In dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4020(01)96571-8