4-[(tert-butyldimethylsilyl)oxy]-5-phenyl-2-(pyridin-2-yl)thiazole

Base Information

• Chemical Name: 4-[(tert-butyldimethylsilyl)oxy]-5-phenyl-2-(pyridin-2-yl)thiazole
• CAS No.: 1380113-33-6
• Molecular Formula: C₂₀H₂₄N₂OSSi
• Molecular Weight: 368.575
• Mol file: 1380113-33-6.mol

Synonyms:4-[(tert-butyldimethylsilyl)oxy]-5-phenyl-2-(pyridin-2-yl)thiazole

Chemical Property of 4-[(tert-butyldimethylsilyl)oxy]-5-phenyl-2-(pyridin-2-yl)thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(tert-butyldimethylsilyl)oxy]-5-phenyl-2-(pyridin-2-yl)thiazole

There total 3 articles about 4-[(tert-butyldimethylsilyl)oxy]-5-phenyl-2-(pyridin-2-yl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5-phenyl-2-(pyridin-2-yl)-1,3-thiazol-4-ol (1233941-64-4) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-[(tert-butyldimethylsilyl)oxy]-5-phenyl-2-(pyridin-2-yl)thiazole (1380113-33-6)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/ejoc.201200140

Reference yield:

pyridine-2-carbothioamide (5346-38-3) → 4-[(tert-butyldimethylsilyl)oxy]-5-phenyl-2-(pyridin-2-yl)thiazole (1380113-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: 1H-imidazole / dichloromethane / 3 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; In dichloromethane; 1: Hantzsch synthesis;

DOI:10.1002/ejoc.201200140

Reference yield:

ethyl 2-phenyl-2-bromoacetate (2882-19-1,2216-90-2) → 4-[(tert-butyldimethylsilyl)oxy]-5-phenyl-2-(pyridin-2-yl)thiazole (1380113-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: 1H-imidazole / dichloromethane / 3 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; In dichloromethane; 1: Hantzsch synthesis;

DOI:10.1002/ejoc.201200140

upstream raw materials:

pyridine-2-carbothioamide

5-phenyl-2-(pyridin-2-yl)-1,3-thiazol-4-ol

tert-butyldimethylsilyl chloride

ethyl 2-phenyl-2-bromoacetate

Downstream raw materials:

C₁₄H₉N₂OS^(1-)