4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-cyano-phenyl)

Base Information

Chemical Name:4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-cyano-phenyl)
CAS No.:1407834-20-1
Molecular Formula:C₁₉H₁₆BrN₅
Molecular Weight:394.274
Hs Code.:

Synonyms:4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-cyano-phenyl)

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Chemical Property of 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-cyano-phenyl)

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Technology Process of 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-cyano-phenyl)

There total 5 articles about 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-cyano-phenyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1407833-64-0
5,6-dihydro-1,4-dimethyl-8-bromo-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine

: 1407834-20-1
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-cyano-phenyl)

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 180 ℃; for 0.5h; under 12901.3 Torr; Microwave irradiation;

Reference yield:

: 1407833-48-0
methyl 3-(5-bromo-2-nitrophenylamino)-2-methylpropanoate

: 1407834-20-1
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-cyano-phenyl)

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium chloride; iron / ethanol; water / 2 h / 60 °C

2: sodium / methanol / 0 - 20 °C

3: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

4: butan-1-ol / 12 h / 130 °C

5: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 180 °C / 12901.3 Torr / Microwave irradiation

With Lawessons reagent; sodium; iron; potassium carbonate; ammonium chloride; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1407833-52-6
methyl 3-(2-amino-5-bromophenylamino)-2-methylpropanoate

: 1407834-20-1
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-cyano-phenyl)

Guidance literature:: Multi-step reaction with 4 steps

1: sodium / methanol / 0 - 20 °C

2: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

3: butan-1-ol / 12 h / 130 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 180 °C / 12901.3 Torr / Microwave irradiation

With Lawessons reagent; sodium; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; butan-1-ol;