benzyl[2-[2-(1-aminocyclopropyl)phenoxy]ethyl]methylcarbamate trifluoroacetic acid salt

Base Information

Chemical Name:benzyl[2-[2-(1-aminocyclopropyl)phenoxy]ethyl]methylcarbamate trifluoroacetic acid salt
CAS No.:1232287-13-6
Molecular Formula:C₂HF₃O₂*C₂₀H₂₄N₂O₃
Molecular Weight:454.446
Hs Code.:

Synonyms:benzyl[2-[2-(1-aminocyclopropyl)phenoxy]ethyl]methylcarbamate trifluoroacetic acid salt

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Chemical Property of benzyl[2-[2-(1-aminocyclopropyl)phenoxy]ethyl]methylcarbamate trifluoroacetic acid salt

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Technology Process of benzyl[2-[2-(1-aminocyclopropyl)phenoxy]ethyl]methylcarbamate trifluoroacetic acid salt

There total 2 articles about benzyl[2-[2-(1-aminocyclopropyl)phenoxy]ethyl]methylcarbamate trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232287-10-3
benzyl[2-(2-cyanophenoxy)ethyl]methylcarbamate

: 557-20-0
diethylzinc

: 76-05-1
trifluoroacetic acid

: 1232287-13-6
benzyl[2-[2-(1-aminocyclopropyl)phenoxy]ethyl]methylcarbamate trifluoroacetic acid salt

Guidance literature:: benzyl[2-(2-cyanophenoxy)ethyl]methylcarbamate; With triisopropoxytitanium(IV) chloride; [2,2]bipyridinyl; methyllithium; isopropyl alcohol; lithium iodide; In 2-methyltetrahydrofuran; toluene; at 0 - 20 ℃; for 0.5h; Inert atmosphere; Large scale;

diethylzinc; In 2-methyltetrahydrofuran; toluene; at 20 ℃; for 30h; Inert atmosphere; Large scale;

trifluoroacetic acid; In Isopropyl acetate; at 0 - 55 ℃; for 21.5h; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.1c00283

Reference yield:

: C₁₀H₁₂N₂O*ClH

: 1232287-13-6
benzyl[2-[2-(1-aminocyclopropyl)phenoxy]ethyl]methylcarbamate trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tert-butyl methyl ether / 4 h / 5 - 20 °C / Inert atmosphere; Large scale

1.2: 13 h / Inert atmosphere; Large scale

2.1: methyllithium; [2,2]bipyridinyl; lithium iodide; triisopropoxytitanium(IV) chloride; isopropyl alcohol / 2-methyltetrahydrofuran; toluene / 0.5 h / 0 - 20 °C / Inert atmosphere; Large scale

2.2: Kulinkovich-De Meijere Reaction / 30 h / 20 °C / Inert atmosphere; Large scale

2.3: 21.5 h / 0 - 55 °C / Inert atmosphere; Large scale

With triisopropoxytitanium(IV) chloride; [2,2]bipyridinyl; methyllithium; triethylamine; isopropyl alcohol; lithium iodide; In 2-methyltetrahydrofuran; tert-butyl methyl ether; toluene; 2.1: |Kulinkovich-De Meijere Reaction;
DOI:10.1021/acs.oprd.1c00283