methyl 3-[3-[1-[2-[2-[(benzyloxycarbonyl)methylamino]ethoxy]phenyl]cyclopropylamino]-5-bromo-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methylbenzoate

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Chemical Name:methyl 3-[3-[1-[2-[2-[(benzyloxycarbonyl)methylamino]ethoxy]phenyl]cyclopropylamino]-5-bromo-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methylbenzoate
CAS No.:1232287-20-5
Molecular Formula:C₃₃H₃₂BrFN₄O₆
Molecular Weight:679.543
Hs Code.:

Synonyms:methyl 3-[3-[1-[2-[2-[(benzyloxycarbonyl)methylamino]ethoxy]phenyl]cyclopropylamino]-5-bromo-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methylbenzoate

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Chemical Property of methyl 3-[3-[1-[2-[2-[(benzyloxycarbonyl)methylamino]ethoxy]phenyl]cyclopropylamino]-5-bromo-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methylbenzoate

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Technology Process of methyl 3-[3-[1-[2-[2-[(benzyloxycarbonyl)methylamino]ethoxy]phenyl]cyclopropylamino]-5-bromo-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methylbenzoate

There total 15 articles about methyl 3-[3-[1-[2-[2-[(benzyloxycarbonyl)methylamino]ethoxy]phenyl]cyclopropylamino]-5-bromo-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095006-01-1
3-(3,5-dibromo-2-oxo-2H-pyrazin-1-yl)-5-fluoro-4-methyl-benzoic acid, methyl ester

: 1232287-12-5
benzyl[2-[2-(1-aminocyclopropyl)phenoxy]ethyl]methylcarbamate

: 1232287-20-5
methyl 3-[3-[1-[2-[2-[(benzyloxycarbonyl)methylamino]ethoxy]phenyl]cyclopropylamino]-5-bromo-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methylbenzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;

Reference yield:

: 1232287-16-9
methyl 3-amino-5-fluoro-4-methylbenzoate sulfuric acid salt

: 1232287-20-5
methyl 3-[3-[1-[2-[2-[(benzyloxycarbonyl)methylamino]ethoxy]phenyl]cyclopropylamino]-5-bromo-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;

Reference yield:

: 1095006-01-1
3-(3,5-dibromo-2-oxo-2H-pyrazin-1-yl)-5-fluoro-4-methyl-benzoic acid, methyl ester

: 1232287-13-6
benzyl[2-[2-(1-aminocyclopropyl)phenoxy]ethyl]methylcarbamate trifluoroacetic acid salt

: 1232287-20-5
methyl 3-[3-[1-[2-[2-[(benzyloxycarbonyl)methylamino]ethoxy]phenyl]cyclopropylamino]-5-bromo-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methylbenzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In toluene; at 95 ℃; for 3.25h; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.1c00283