5-bromo-4-chloro-1-[(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine]

Base Information

Chemical Name:5-bromo-4-chloro-1-[(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine]
CAS No.:1596337-81-3
Molecular Formula:C₁₄H₁₀BrClN₂O₂S
Molecular Weight:385.669
Hs Code.:

Synonyms:5-bromo-4-chloro-1-[(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine]

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Chemical Property of 5-bromo-4-chloro-1-[(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine]

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Technology Process of 5-bromo-4-chloro-1-[(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine]

There total 6 articles about 5-bromo-4-chloro-1-[(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 876343-82-7
5-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine

: 98-59-9
p-toluenesulfonyl chloride

: 1596337-81-3
5-bromo-4-chloro-1-[(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine]

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h; Temperature;

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1596337-81-3
5-bromo-4-chloro-1-[(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine]

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 50 °C / Inert atmosphere

2.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / 78 °C / Inert atmosphere

2.2: 2 h

3.1: potassium fluoride / methanol / 1 h / 20 °C

4.1: N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.2: 3 h

With potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride; sec.-butyllithium; sodium hydride; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; mineral oil;
DOI:10.1002/cmdc.201300520

Reference yield:

: 651744-48-8
4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine

: 1596337-81-3
5-bromo-4-chloro-1-[(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine]

Guidance literature:: Multi-step reaction with 3 steps

1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / 78 °C / Inert atmosphere

1.2: 2 h

2.1: potassium fluoride / methanol / 1 h / 20 °C

3.1: N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: 3 h

With potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride; sec.-butyllithium; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; cyclohexane;
DOI:10.1002/cmdc.201300520