(1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol

Base Information

Chemical Name:(1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol
CAS No.:1615201-21-2
Molecular Formula:C₁₈H₁₈N₄O₃S
Molecular Weight:370.432
Hs Code.:

Synonyms:(1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol

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Chemical Property of (1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol

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Technology Process of (1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol

There total 4 articles about (1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1615201-43-8
2-((4-azidophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline

: 107-19-7
propargyl alcohol

: 1615201-21-2
(1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol

Guidance literature:: With copper(ll) sulfate pentahydrate; Vitamin C; In water; tert-butyl alcohol; at 20 ℃;
DOI:10.1016/j.ejmech.2014.05.019

Reference yield:

: 52374-24-0
N-(4-nitrobenzenesulfonyl)-2-phenylethylamine

: 1615201-21-2
(1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: formic acid / 2 h / 20 °C / Reflux

2.1: tin(II) chloride dihdyrate / ethanol / 4 h / Reflux

3.1: hydrogenchloride; sodium nitrite / ethanol; water / 0.25 h

3.2: 0.5 h / 20 °C

4.1: copper(ll) sulfate pentahydrate; Vitamin C / water; tert-butyl alcohol / 20 °C

With hydrogenchloride; copper(ll) sulfate pentahydrate; tin(II) chloride dihdyrate; Vitamin C; sodium nitrite; In formic acid; ethanol; water; tert-butyl alcohol; 1.1: |Pictet-Spengler Synthesis;
DOI:10.1016/j.ejmech.2014.05.019

Reference yield:

: 64880-92-8
2-((4-nitrophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline

: 1615201-21-2
(1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(II) chloride dihdyrate / ethanol / 4 h / Reflux

2.1: hydrogenchloride; sodium nitrite / ethanol; water / 0.25 h

2.2: 0.5 h / 20 °C

3.1: copper(ll) sulfate pentahydrate; Vitamin C / water; tert-butyl alcohol / 20 °C

With hydrogenchloride; copper(ll) sulfate pentahydrate; tin(II) chloride dihdyrate; Vitamin C; sodium nitrite; In ethanol; water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2014.05.019