4-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLSULFONYL)ANILINE

Base Information

• Chemical Name: 4-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLSULFONYL)ANILINE
• CAS No.: 7252-02-0
• Molecular Formula: C15H16N2O2S
• Molecular Weight: 288.37
• Mol file: 7252-02-0.mol

Synonyms:4-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)aniline;2-sulfanilyl-1,2,3,4-tetrahydro-isoquinoline;benzenamine,4-[(3,4-dihydro-2(1h)-isoquinolinyl)sulfonyl];2-Sulfanilyl-1,2,3,4-tetrahydro-isochinolin;

Chemical Property of 4-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLSULFONYL)ANILINE

Chemical Property:

• Vapor Pressure: 3.63E-10mmHg at 25°C
• Boiling Point: 500.9°Cat760mmHg
• Flash Point: 256.8°C
• PSA: 71.78000
• Density: 1.329g/cm³
• LogP: 3.61570

Purity/Quality:

99% ^*data from raw suppliers

4-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)aniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLSULFONYL)ANILINE

There total 7 articles about 4-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLSULFONYL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-((4-nitrophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline (64880-92-8) → 2-((4-aminophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline (7252-02-0)

Guidance literature:

With methanol; palladium on activated charcoal; at 20 ℃;

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → 2-((4-aminophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline (7252-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; acetone

2: zinc; ammonium chloride

With pyridine; ammonium chloride; acetone; zinc;

DOI:10.1021/ja01123a025

Reference yield:

→ 2-((4-aminophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline (7252-02-0)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

2-((4-nitrophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline

1-(2-bromo-ethyl)-2-bromomethyl-benzene

sulfanilamide

1,2,3,4-tetrahydroisoquinoline

Downstream raw materials:

(1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol

2-((4-(4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline

2-((4-azidophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline

2-((4-(4-((o-tolyloxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline