2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylmethyl)benzamide

Base Information

Chemical Name:2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylmethyl)benzamide
CAS No.:1362818-07-2
Molecular Formula:C₂₇H₂₈FN₅O₄
Molecular Weight:505.549
Hs Code.:

Synonyms:2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylmethyl)benzamide

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Chemical Property of 2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylmethyl)benzamide

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Technology Process of 2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylmethyl)benzamide

There total 10 articles about 2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1362818-03-8
5-bromo-2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-4-(4-morpholinylmethyl)benzamide

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1362818-07-2
2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylmethyl)benzamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 120 ℃; for 0.583333h; Microwave irradiation;

Reference yield:

: 50-85-1
2-hydroxy-p-toluic acid

: 1362818-07-2
2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylmethyl)benzamide

Guidance literature:: Multi-step reaction with 10 steps

1: thionyl chloride / 24 h / 50 °C

2: bromine / chloroform / 1 h / 0 °C

3: pyridine / 4 h

4: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / Reflux

5: triethylamine / acetone / 0.5 h

6: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 50 °C

7: potassium carbonate / N,N-dimethyl-formamide / 20 °C

8: water; lithium hydroxide / tetrahydrofuran / 4 h / 50 °C

9: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h

10: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.58 h / 120 °C / Microwave irradiation

With pyridine; N-Bromosuccinimide; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; water; bromine; sodium carbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; chloroform; N,N-dimethyl-formamide; acetone;

Reference yield:

: 4670-56-8
methyl 2-hydroxy-4-methylbenzoate

: 1362818-07-2
2-{[(4-fluorophenyl)methyl]oxy}-N-(3-methyl-4-isoxazolyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylmethyl)benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: bromine / chloroform / 1 h / 0 °C

2: pyridine / 4 h

3: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / Reflux

4: triethylamine / acetone / 0.5 h

5: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 50 °C

6: potassium carbonate / N,N-dimethyl-formamide / 20 °C

7: water; lithium hydroxide / tetrahydrofuran / 4 h / 50 °C

8: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h

9: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.58 h / 120 °C / Microwave irradiation

With pyridine; N-Bromosuccinimide; 1-hydroxy-7-aza-benzotriazole; water; bromine; sodium carbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; chloroform; N,N-dimethyl-formamide; acetone;