N-(3-(5,6-dihydro-4-t-butoxycarbonyl-[1,2,4]-triazin-1-yl)anilino-(2R)-2-hydroxypropyl)-5-chloro-2-thiophene carboxamide

Base Information

Chemical Name:N-(3-(5,6-dihydro-4-t-butoxycarbonyl-[1,2,4]-triazin-1-yl)anilino-(2R)-2-hydroxypropyl)-5-chloro-2-thiophene carboxamide
CAS No.:1261138-18-4
Molecular Formula:C₂₂H₂₈ClN₅O₄S
Molecular Weight:494.014
Hs Code.:

Synonyms:N-(3-(5,6-dihydro-4-t-butoxycarbonyl-[1,2,4]-triazin-1-yl)anilino-(2R)-2-hydroxypropyl)-5-chloro-2-thiophene carboxamide

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Chemical Property of N-(3-(5,6-dihydro-4-t-butoxycarbonyl-[1,2,4]-triazin-1-yl)anilino-(2R)-2-hydroxypropyl)-5-chloro-2-thiophene carboxamide

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Technology Process of N-(3-(5,6-dihydro-4-t-butoxycarbonyl-[1,2,4]-triazin-1-yl)anilino-(2R)-2-hydroxypropyl)-5-chloro-2-thiophene carboxamide

There total 8 articles about N-(3-(5,6-dihydro-4-t-butoxycarbonyl-[1,2,4]-triazin-1-yl)anilino-(2R)-2-hydroxypropyl)-5-chloro-2-thiophene carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1261138-18-4
N-(3-(5,6-dihydro-4-t-butoxycarbonyl-[1,2,4]-triazin-1-yl)anilino-(2R)-2-hydroxypropyl)-5-chloro-2-thiophene carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 19 h / 80 °C

1.2: 1 h / 0 °C

2.1: phosphorus tribromide / 1,2-dimethoxyethane / 4.5 h / 0 - 60 °C

2.2: 0.5 h / pH 4

3.1: sodium acetate / 1,2-dimethoxyethane / 15 h / Reflux

4.1: dmap / tetrahydrofuran / 1.5 h / Reflux

5.1: zinc; ammonium chloride / methanol / 13 h / 65 °C

6.1: 2-methyl-propan-1-ol / 18 h / Reflux

With sodium acetate; phosphorus tribromide; potassium carbonate; ammonium chloride; zinc; dmap; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 2-methyl-propan-1-ol; acetonitrile;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1261138-18-4
N-(3-(5,6-dihydro-4-t-butoxycarbonyl-[1,2,4]-triazin-1-yl)anilino-(2R)-2-hydroxypropyl)-5-chloro-2-thiophene carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / tetrahydrofuran / 1.5 h / Reflux

2: zinc; ammonium chloride / methanol / 13 h / 65 °C

3: 2-methyl-propan-1-ol / 18 h / Reflux

With ammonium chloride; zinc; dmap; In tetrahydrofuran; methanol; 2-methyl-propan-1-ol;

Reference yield:

: 1261138-14-0
1-bromo-2-[N-(4-nitro-phenyl)-hydrazino]-ethane

: 1261138-18-4
N-(3-(5,6-dihydro-4-t-butoxycarbonyl-[1,2,4]-triazin-1-yl)anilino-(2R)-2-hydroxypropyl)-5-chloro-2-thiophene carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium acetate / 1,2-dimethoxyethane / 15 h / Reflux

2: dmap / tetrahydrofuran / 1.5 h / Reflux

3: zinc; ammonium chloride / methanol / 13 h / 65 °C

4: 2-methyl-propan-1-ol / 18 h / Reflux

With sodium acetate; ammonium chloride; zinc; dmap; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 2-methyl-propan-1-ol;