(S_S,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-1-phenyl-methylphosphonate

Base Information

• Chemical Name: (S_S,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-1-phenyl-methylphosphonate
• CAS No.: 201610-50-6
• Molecular Formula: C₁₈H₂₄NO₄PS
• Molecular Weight: 381.433

Synonyms:(S_S,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-1-phenyl-methylphosphonate

Chemical Property of (S_S,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-1-phenyl-methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S_S,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-1-phenyl-methylphosphonate

There total 3 articles about (S_S,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-1-phenyl-methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diethyl phosphonate (762-04-9,123-22-8) + (S,E)-N-benzylidene-4-methylbenzenesulfinamide (350479-90-2) → [(S)-Phenyl-((S)-toluene-4-sulfinylamino)-methyl]-phosphonic acid diethyl ester (197293-91-7) + (SS,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-1-phenyl-methylphosphonate (201610-50-6)

Guidance literature:

With lithium hexamethyldisilazane; Multistep reaction. Title compound not separated from byproducts; 1.) THF, -78 deg C, 2.) THF, -78 deg C, 2 h;

DOI:10.1016/S0957-4166(97)00606-X

Reference yield:

(-)-menthyl p-toluenesulfinate (1517-82-4) → (SS,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-1-phenyl-methylphosphonate (201610-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LiHMDS, 2.) CsF / 1.) THF, -78 deg C, 2.) 0 deg C

2: tetrahydrofuran / -78 °C

With cesium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/jo971394o

Reference yield:

benzaldehyde (100-52-7) → (SS,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-1-phenyl-methylphosphonate (201610-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LiHMDS, 2.) CsF / 1.) THF, -78 deg C, 2.) 0 deg C

2: tetrahydrofuran / -78 °C

With cesium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/jo971394o

upstream raw materials:

Diethyl phosphonate

(S,E)-N-benzylidene-4-methylbenzenesulfinamide

(-)-menthyl p-toluenesulfinate

benzaldehyde

Downstream raw materials:

(R)-(+)-O,O-diethyl 1-amino-1-phenylmethylphosphonate

(R)-1-amino-1-phenylmethylphosphonic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 201610-50-6 (S_S,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-1-phenyl-methylphosphonate

Send

Send

Metric Ton KG G Pound L ML

Send

Send