3-Methoxy-4-(trifluoromethyl)benzaldehyde

Base Information

• Chemical Name: 3-Methoxy-4-(trifluoromethyl)benzaldehyde
• CAS No.: 945003-38-3
• Molecular Formula: C₉H₇F₃O₂
• Molecular Weight: 204.149
• Hs Code.: 2913000090
• Mol file: 945003-38-3.mol

Synonyms:4-trifluoromethyl-3- methoxybenzaldehyde

Chemical Property of 3-Methoxy-4-(trifluoromethyl)benzaldehyde

Chemical Property:

• Refractive Index: 1.4880
• Sensitive.: Air Sensitive

Purity/Quality:

97% ^*data from raw suppliers

3-Methoxy-4-(trifluoromethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Methoxy-4-(trifluoromethyl)benzaldehyde is a useful reactant for the preparation of 2-?methoxyacylhydrazones as selective PDE10A inhibitors.

Technology Process of 3-Methoxy-4-(trifluoromethyl)benzaldehyde

There total 3 articles about 3-Methoxy-4-(trifluoromethyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-methoxy-4-(trifluoromethyl)benzonitrile (447-93-8) → 4-trifluoromethyl-3- methoxybenzaldehyde (945003-38-3)

Guidance literature:

3-methoxy-4-(trifluoromethyl)benzonitrile; With diisobutylaluminium hydride; In toluene; at -10 - 0 ℃; for 1h;

With hydrogenchloride; water; In toluene;

Reference yield: 38.0%

3-fluoro-4-(trifluoromethyl)benzoic acid (115754-21-7) + sodium ethanolate (141-52-6) → 4-trifluoromethyl-3- methoxybenzaldehyde (945003-38-3)

Guidance literature:

3-fluoro-4-(trifluoromethyl)benzoic acid; sodium ethanolate; In methanol; dimethyl sulfoxide; for 3h; Heating / reflux;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With sodium hydroxide; Dess-Martin periodane; more than 3 stages;

Reference yield:

→ 4-trifluoromethyl-3- methoxybenzaldehyde (945003-38-3)

Guidance literature:

With Dess-Martin periodane; In chloroform; at 20 ℃; for 1h; Cooling with ice;

upstream raw materials:

3-methoxy-4-(trifluoromethyl)benzonitrile

3-fluoro-4-(trifluoromethyl)benzoic acid

sodium ethanolate

Downstream raw materials:

(E)-4-(3-methoxy-4-trifluoromethyl-phenyl)-but-3-en-2-one

2-(cyclopropylamino)-4-hydroxy-6-(3-methoxy-4-(trifluoromethyl)phenyl)pyrimidine-5-carbonitrile

C₂₀H₁₉F₃N₂O₅

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