(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid

Base Information

Chemical Name:(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid
CAS No.:860791-95-3
Molecular Formula:C₂₅H₂₁NO₅
Molecular Weight:415.445
Hs Code.:

Synonyms:(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid

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Chemical Property of (+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid

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Technology Process of (+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid

There total 5 articles about (+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 860791-92-0
(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid allyl ester

: 860791-95-3
(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/jm049402y

Reference yield:

: 860791-86-2
3-hydroxy-4-(1H-pyrrol-1-yl)benzoic acid

: 860791-95-3
(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 63 percent / cesium fluoride / dimethylformamide / 20 °C

2.1: NaH / tetrahydrofuran / 1 h / 20 °C

2.2: 98 percent / tetrahydrofuran / 17 h / 20 °C

3.1: 97 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾; morpholine / tetrahydrofuran / 0.5 h / 20 °C

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; cesium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm049402y

Reference yield:

: 860791-87-3
3-hydroxy-4-(1H-pyrrol-1-yl)benzoic acid ethyl ester

: 860791-95-3
(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 20 °C

1.2: 98 percent / tetrahydrofuran / 17 h / 20 °C

2.1: 97 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾; morpholine / tetrahydrofuran / 0.5 h / 20 °C

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm049402y