(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid allyl ester

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Chemical Name:(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid allyl ester
CAS No.:860791-92-0
Molecular Formula:C₂₈H₂₅NO₅
Molecular Weight:455.51
Hs Code.:

Synonyms:(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid allyl ester

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Chemical Property of (+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid allyl ester

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Technology Process of (+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid allyl ester

There total 3 articles about (+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 860791-87-3
3-hydroxy-4-(1H-pyrrol-1-yl)benzoic acid ethyl ester

: (+/-)-α-bromonaphth-1-ylacetic acid allyl ester

: 860791-92-0
(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid allyl ester

Guidance literature:: 3-hydroxy-4-(1H-pyrrol-1-yl)benzoic acid ethyl ester; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

(+/-)-α-bromonaphth-1-ylacetic acid allyl ester; In tetrahydrofuran; at 20 ℃; for 17h;
DOI:10.1021/jm049402y

Reference yield:

: 860791-86-2
3-hydroxy-4-(1H-pyrrol-1-yl)benzoic acid

: 860791-92-0
(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 63 percent / cesium fluoride / dimethylformamide / 20 °C

2.1: NaH / tetrahydrofuran / 1 h / 20 °C

2.2: 98 percent / tetrahydrofuran / 17 h / 20 °C

With sodium hydride; cesium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm049402y

Reference yield:

: 2374-03-0
4-aminosalicylic acid

: 860791-92-0
(+/-)-α-[1-ethoxycarbonyl-3-[4-(1H-pyrrol-1-yl)phenyl]oxy]naphth-1-ylacetic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 76 percent / acetic acid / 100 °C

2.1: 63 percent / cesium fluoride / dimethylformamide / 20 °C

3.1: NaH / tetrahydrofuran / 1 h / 20 °C

3.2: 98 percent / tetrahydrofuran / 17 h / 20 °C

With sodium hydride; acetic acid; cesium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Clauson-Kaas reaction;
DOI:10.1021/jm049402y