[(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane

Base Information

Chemical Name:[(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane
CAS No.:921630-48-0
Molecular Formula:C₂₀H₃₅NO₂Si
Molecular Weight:349.589
Hs Code.:

Synonyms:[(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane

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Chemical Property of [(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane

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Technology Process of [(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane

There total 7 articles about [(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026786-89-9
[(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{(1E)-3-methoxyprop-1-en-1-yl}benzyl)amino]cyclopropane

: 921630-48-0
[(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 1.5h;

Reference yield:

: 199177-26-9
3-bromo-5-hydroxybenzaldehyde

: 921630-48-0
[(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; sodium carbonate; triphenylphosphine / water; N,N-dimethyl-formamide / 16 h / 80 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3: magnesium sulfate / dichloromethane / 12 h / 20 °C

4: sodium tetrahydroborate / methanol / 0 - 20 °C

5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; palladium diacetate; sodium carbonate; magnesium sulfate; triphenylphosphine; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.02.067

Reference yield:

: 1026786-84-4
3-hydroxy-5-[(1E)-3-(methyloxy)-1-propen-1-yl]benzaldehyde

: 921630-48-0
[(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

2: magnesium sulfate / dichloromethane / 12 h / 20 °C

3: sodium tetrahydroborate / methanol / 0 - 20 °C

4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; magnesium sulfate; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.02.067