2-(3-benzyloxy-4-methoxy-5-nitrophenyl)-2-(tert-butyldimethylsilyloxy)nitroethane

Base Information

Chemical Name:2-(3-benzyloxy-4-methoxy-5-nitrophenyl)-2-(tert-butyldimethylsilyloxy)nitroethane
CAS No.:312327-26-7
Molecular Formula:C₂₂H₃₀N₂O₇Si
Molecular Weight:462.575
Hs Code.:

Synonyms:2-(3-benzyloxy-4-methoxy-5-nitrophenyl)-2-(tert-butyldimethylsilyloxy)nitroethane

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Chemical Property of 2-(3-benzyloxy-4-methoxy-5-nitrophenyl)-2-(tert-butyldimethylsilyloxy)nitroethane

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Technology Process of 2-(3-benzyloxy-4-methoxy-5-nitrophenyl)-2-(tert-butyldimethylsilyloxy)nitroethane

There total 4 articles about 2-(3-benzyloxy-4-methoxy-5-nitrophenyl)-2-(tert-butyldimethylsilyloxy)nitroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6635-20-7
isonitrovanillin

: 312327-26-7
2-(3-benzyloxy-4-methoxy-5-nitrophenyl)-2-(tert-butyldimethylsilyloxy)nitroethane

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / AlCl₃; pyridine / CHCl₃ / 24 h / Heating

2: 93 percent / dimethylformamide / 48 h / 140 °C

3: 92 percent / KOH; benzyltriethylammonium chloride / CHCl₃ / 36 h / 20 °C

4: Amberlyst A-21 ion-exchange resin / tetrahydrofuran / 3 h / 20 °C

5: 1.86 g / 2,6-lutidine / tetrahydrofuran / 2 h / 0 - 20 °C

With pyridine; 2,6-dimethylpyridine; potassium hydroxide; aluminium trichloride; Amberlyst A-21 ion-exchange resin; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; 1: ether cleavage / 2: Alkylation / 3: Methylation / 4: Addition / 5: silylation;
DOI:10.1021/jo001080s

Reference yield:

: 116313-85-0
3,4-dihydroxy-5-nitrobenzaldehyde

: 312327-26-7
2-(3-benzyloxy-4-methoxy-5-nitrophenyl)-2-(tert-butyldimethylsilyloxy)nitroethane

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / dimethylformamide / 48 h / 140 °C

2: 92 percent / KOH; benzyltriethylammonium chloride / CHCl₃ / 36 h / 20 °C

3: Amberlyst A-21 ion-exchange resin / tetrahydrofuran / 3 h / 20 °C

4: 1.86 g / 2,6-lutidine / tetrahydrofuran / 2 h / 0 - 20 °C

With 2,6-dimethylpyridine; potassium hydroxide; Amberlyst A-21 ion-exchange resin; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; 1: Alkylation / 2: Methylation / 3: Addition / 4: silylation;
DOI:10.1021/jo001080s

Reference yield:

: 312327-14-3
3-benzyloxy-4-methoxy-5-nitrobenzaldehyde

: 312327-26-7
2-(3-benzyloxy-4-methoxy-5-nitrophenyl)-2-(tert-butyldimethylsilyloxy)nitroethane

Guidance literature:: Multi-step reaction with 2 steps

1: Amberlyst A-21 ion-exchange resin / tetrahydrofuran / 3 h / 20 °C

2: 1.86 g / 2,6-lutidine / tetrahydrofuran / 2 h / 0 - 20 °C

With 2,6-dimethylpyridine; Amberlyst A-21 ion-exchange resin; In tetrahydrofuran; 1: Addition / 2: silylation;
DOI:10.1021/jo001080s