2-bromo-6-trifluoromethybenzenesulfonic acid

Base Information

• Chemical Name: 2-bromo-6-trifluoromethybenzenesulfonic acid
• CAS No.: 1431291-89-2
• Molecular Formula: C₇H₄BrF₃O₃S
• Molecular Weight: 305.072
• Mol file: 1431291-89-2.mol

Synonyms:2-bromo-6-trifluoromethybenzenesulfonic acid

Chemical Property of 2-bromo-6-trifluoromethybenzenesulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-6-trifluoromethybenzenesulfonic acid

There total 7 articles about 2-bromo-6-trifluoromethybenzenesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-bromo-4-amino-6-trifluoromethybenzenesulfonic acid (1431291-90-5) → 2-bromo-6-trifluoromethybenzenesulfonic acid (1431291-89-2)

Guidance literature:

2-bromo-4-amino-6-trifluoromethybenzenesulfonic acid; With n-Butyl nitrite; sodium; In ethanol; at 0 - 60 ℃; for 3h;

With sulfuric acid; copper(l) chloride; at 0 ℃; for 2h; Reflux;

DOI:10.3184/174751913X13619014318618

Reference yield:

N-(3-bromo-5-trifluoromethyl-phenyl)-acetamide (453560-57-1) → 2-bromo-6-trifluoromethybenzenesulfonic acid (1431291-89-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid; copper(l) chloride; sulfur dioxide / 2.5 h / 0 - 5 °C

2.1: hydrogenchloride / ethanol / 2 h / Reflux

3.1: n-Butyl nitrite; sodium / ethanol / 3 h / 0 - 60 °C

3.2: 2 h / 0 °C / Reflux

With hydrogenchloride; n-Butyl nitrite; sulfur dioxide; sodium; acetic acid; copper(l) chloride; In ethanol;

DOI:10.3184/174751913X13619014318618

Reference yield:

4-nitro-2-trifluoromethyl-aniline (121-01-7) → 2-bromo-6-trifluoromethybenzenesulfonic acid (1431291-89-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: hydrogen bromide / 0.17 h / 20 - 70 °C

1.2: 3 h / 60 - 70 °C

2.1: tin(ll) chloride / ethanol / 3 h / Reflux

3.1: 1,2-dichloro-ethane / 0.5 h / 20 °C

3.2: 2 h / 50 °C

4.1: acetic acid; hydrogenchloride; sulfuric acid / 0.5 h / 0 - 2 °C

4.2: 1 h / 0 - 5 °C

5.1: acetic acid; copper(l) chloride; sulfur dioxide / 2.5 h / 0 - 5 °C

6.1: hydrogenchloride / ethanol / 2 h / Reflux

7.1: n-Butyl nitrite; sodium / ethanol / 3 h / 0 - 60 °C

7.2: 2 h / 0 °C / Reflux

With hydrogenchloride; n-Butyl nitrite; sulfuric acid; sulfur dioxide; hydrogen bromide; sodium; acetic acid; copper(l) chloride; tin(ll) chloride; In ethanol; 1,2-dichloro-ethane;

DOI:10.3184/174751913X13619014318618

upstream raw materials:

4-nitro-2-trifluoromethyl-aniline

N-(3-bromo-5-trifluoromethyl-phenyl)-acetamide

2-bromo-4-nitro-6-trifluoromethylaniline

2-bromo-4-amino-6-trifluoromethylaniline

Downstream raw materials:

C₇H₃BrF₃O₃S^(1-)*K⁽¹⁺⁾

2-bromo-6-trifluoromethyl-N-(5,8-dimethoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-yl)benzenesulfonamide

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