But-3-enyl-{(S)-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-butyl}-amine

Base Information

Chemical Name:But-3-enyl-{(S)-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-butyl}-amine
CAS No.:868745-24-8
Molecular Formula:C₂₀H₃₇N
Molecular Weight:291.52
Hs Code.:

Synonyms:But-3-enyl-{(S)-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-butyl}-amine

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Chemical Property of But-3-enyl-{(S)-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-butyl}-amine

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Technology Process of But-3-enyl-{(S)-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-butyl}-amine

There total 5 articles about But-3-enyl-{(S)-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-butyl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1-[(E)-2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-vinyl]-butylamine

: 5162-44-7
1-bromo-4-butene

: 868745-24-8
But-3-enyl-{(S)-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-butyl}-amine

Guidance literature:: With cesium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 106h;
DOI:10.1021/ol052034n

Reference yield:

: 66703-03-5
trans-1-iodo-1-pentene

: 868745-24-8
But-3-enyl-{(S)-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-butyl}-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuLi / diethyl ether; pentane / 2.5 h / -78 - 20 °C

1.2: AlMe₃ / diethyl ether; pentane; hexane / 3 h / -78 °C

2.1: 80 percent / HN₃; DEAD; PPh₃ / benzene / 6 h / 0 - 20 °C

3.1: LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

4.1: 67 percent / CsOH*H₂O / dimethylformamide / 106 h / 20 °C

With cesium hydroxide; lithium aluminium tetrahydride; tris-(2-chloro-ethyl)-amine; tert.-butyl lithium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; pentane; benzene; 2.1: Mitsunobu reaction;
DOI:10.1021/ol052034n

Reference yield:

: 80434-59-9,485843-44-5,796865-68-4
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde

: 868745-24-8
But-3-enyl-{(S)-1-[(E)-2-((1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-vinyl]-butyl}-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuLi / diethyl ether; pentane / 2.5 h / -78 - 20 °C

1.2: AlMe₃ / diethyl ether; pentane; hexane / 3 h / -78 °C

2.1: 80 percent / HN₃; DEAD; PPh₃ / benzene / 6 h / 0 - 20 °C

3.1: LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

4.1: 67 percent / CsOH*H₂O / dimethylformamide / 106 h / 20 °C

With cesium hydroxide; lithium aluminium tetrahydride; tris-(2-chloro-ethyl)-amine; tert.-butyl lithium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; pentane; benzene; 2.1: Mitsunobu reaction;
DOI:10.1021/ol052034n