1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-phenylisoquinoline

Base Information

Chemical Name:1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-phenylisoquinoline
CAS No.:23818-68-0
Molecular Formula:C₂₄H₂₅NO₄S
Molecular Weight:423.533
Hs Code.:

Synonyms:1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-phenylisoquinoline

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Chemical Property of 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-phenylisoquinoline

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Technology Process of 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-phenylisoquinoline

There total 5 articles about 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-phenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 14165-67-4
N-(3,4-dimethoxyphenethyl)-4-methylbenzenesulfonamide

: 100-52-7
benzaldehyde

: 23818-68-0
1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-phenylisoquinoline

Guidance literature:: With boron trifluoride diethyl etherate; thiophenol; In dichloromethane; at 25 ℃; for 17h;
DOI:10.1016/j.tetlet.2006.08.097

Reference yield:

: 4118-36-9
6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

: 98-59-9
p-toluenesulfonyl chloride

: 23818-68-0
1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-phenylisoquinoline

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol200808q

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 23818-68-0
1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-phenylisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / dichloromethane

2: trifluoroacetic acid / 2 h / Reflux

With sodium carbonate; trifluoroacetic acid; In dichloromethane; 2: |Pictet-Spengler Synthesis;
DOI:10.1007/s12272-013-0111-9