N-[1-({2-chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide

Base Information

• Chemical Name: N-[1-({2-chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide
• CAS No.: 1253188-19-0
• Molecular Formula: C₂₄H₁₈ClF₂N₃O₂
• Molecular Weight: 453.876

Synonyms:N-[1-({2-chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide

Chemical Property of N-[1-({2-chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide

Chemical Property:

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Technology Process of N-[1-({2-chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide

There total 1 articles about N-[1-({2-chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(bromomethyl)-1-chloro-3-[(phenylmethyl)oxy]benzene (1253188-18-9) + 2,6-difluoro-N-(1H-pyrazol-3-yl)benzamide (1249343-86-9) → N-[1-({2-chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide (1253188-19-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

N-[1-({2-chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide (1253188-19-0) → N-{1-[(2-chloro-6-hydroxyphenyl)methyl]-1H-pyrazol-3-yl}-2,6-difluorobenzamide (1253188-20-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; 5% Pd(II)/C(eggshell); In ethyl acetate; at 20 ℃; under 750.075 Torr;

upstream raw materials:

2-(bromomethyl)-1-chloro-3-[(phenylmethyl)oxy]benzene

2,6-difluoro-N-(1H-pyrazol-3-yl)benzamide

Downstream raw materials:

N-{1-[(2-chloro-6-hydroxyphenyl)methyl]-1H-pyrazol-3-yl}-2,6-difluorobenzamide

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