5-(S)-Fluorowillardiine

Base Information

• Chemical Name: 5-(S)-Fluorowillardiine
• CAS No.: 1249343-86-9
• Molecular Formula: C₁₀H₇F₂N₃O
• Molecular Weight: 223.182
• Mol file: 1249343-86-9.mol

Synonyms:2,6-difluoro-N-(1H-pyrazol-3-yl)benzamide

Chemical Property of 5-(S)-Fluorowillardiine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

CRACintermediate1 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(S)-Fluorowillardiine

There total 1 articles about 5-(S)-Fluorowillardiine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.77%

3-aminopyrazole (1820-80-0,916420-28-5) + 2,6-difluorobenzoylchloride (18063-02-0) → 2,6-difluoro-N-(1H-pyrazol-3-yl)benzamide (1249343-86-9)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 20 ℃;

DOI:10.1021/jacs.0c02949

Reference yield: 86.14%

2,6-difluoro-N-(1H-pyrazol-3-yl)benzamide (1249343-86-9) + 2-(bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene (239087-08-2) → 2,6-difluoro-N-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide (1253186-49-0)

Guidance literature:

2,6-difluoro-N-(1H-pyrazol-3-yl)benzamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

2-(bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.0c02949

Reference yield:

2-benzylbenzyl bromide (55276-42-1) + 2,6-difluoro-N-(1H-pyrazol-3-yl)benzamide (1249343-86-9) → 2,6-difluoro-N-(1-{[2-(phenylmethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide (1253186-22-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

upstream raw materials:

3-aminopyrazole

2,6-difluorobenzoylchloride

Downstream raw materials:

2,6-difluoro-N-(1-{[2-(phenylmethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide

2,6-difluoro-N-(1-{[2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide

methyl 4-chloro-3-[(3-{[(2,6-difluorophenyl)carbonyl]amino}-1H-pyrazol-1-yl)methyl]benzoate

N-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1249343-86-9 5-(S)-Fluorowillardiine

Send

Send

Metric Ton KG G Pound L ML

Send

Send