Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)-

Base Information

• Chemical Name: Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)-
• CAS No.: 747414-16-0
• Molecular Formula: C23H22O2
• Molecular Weight: 330.426
• Hs Code.: 2909309090
• Mol file: 747414-16-0.mol

Synonyms:Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)-;(4-(prop-1-en-2-yl)-1,3-phenylene)bis(oxy)bis(Methylene)dibenzene;2,4-bis(benzyloxy)-1-(prop-1-en-2-yl)benzene;1-(1-Methylethenyl)-2,4-bis(phenylmethoxy)Benzene;2,4-bis(benzyloxy)-1-isopropenylbenzene

Chemical Property of Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)-

Chemical Property:

• PSA: 18.46000
• LogP: 5.87770
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(((4-(Prop-1-en-2-yl)-1,3-phenylene)bis(oxy))bis(methylene))dibenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)-

There total 7 articles about Benzene, 1-(1-Methylethenyl)-2,4-bis(phenylMethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,4-bis(benzyloxy)acetophenone (22877-01-6) + C18H15BrMgP → (((4-(prop-1-en-2-yl)-1,3-phenylene)bis(oxy))bis(methylene))dibenzene (747414-16-0)

Guidance literature:

C₁₈H₁₅BrMgP; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h; Inert atmosphere;

2,4-bis(benzyloxy)acetophenone; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmcl.2018.10.035

Reference yield: 80.0%

2,4-bis(benzyloxy)acetophenone (22877-01-6) + Methyltriphenylphosphonium bromide (1779-49-3) → (((4-(prop-1-en-2-yl)-1,3-phenylene)bis(oxy))bis(methylene))dibenzene (747414-16-0)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

2,4-bis(benzyloxy)acetophenone; In tetrahydrofuran; hexane; at 20 ℃; for 18h; Further stages.;

DOI:10.1021/jm701018h

Reference yield: 79.5%

2,4-bis(benzyloxy)acetophenone (22877-01-6) → (((4-(prop-1-en-2-yl)-1,3-phenylene)bis(oxy))bis(methylene))dibenzene (747414-16-0)

Guidance literature:

With n-butyllithium; Methyltriphenylphosphonium bromide; In tetrahydrofuran; hexane; at -5 - 20 ℃; Inert atmosphere;

upstream raw materials:

2,4-bis(benzyloxy)acetophenone

Methyltriphenylphosphonium bromide

methyl-triphenylphosphonium iodide

benzyl bromide

Downstream raw materials:

1-(2,4-dihydroxy-5-isopropylphenyl)-5-{4-[(1-methylpiperidin-4-ylamino)methyl]phenyl}-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

1-[2,4-bis(benzyloxy)cumenyl]-5-[p-(hydroxymethyl)phenyl]-1H-1,2,3-triazole

C₃₇H₃₈N₄O₅

1-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-5-(4-morpholin-4-ylmethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid cyclopentylamide

Refernces

• 1、 Kang, Julie,Young Lee, Jun,Ta?, ?sa,More, Kunal N.,Kim, Hangun,Park, Jeong-Hoon,Chang, Dong-Jo. "Radiosynthesis, biological evaluation and preliminary microPET study of 18F-labeled 5-resorcinolic triazolone derivative based on ganetespib targeting HSP90". . p. 3658 - 3664. Retrieved 2018/10/26.
• 2、 -. "Heat shock protein inhibitor and preparation method and application thereof". Paragraph 0094; 0095; 0101; 0102; 0103. . Retrieved 2016/10/09.