2-[N-(4-tert-butylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

Base Information

Chemical Name:2-[N-(4-tert-butylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride
CAS No.:1456906-96-9
Molecular Formula:C₃₃H₄₁N₃O₂*ClH
Molecular Weight:548.168
Hs Code.:

Synonyms:2-[N-(4-tert-butylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

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Chemical Property of 2-[N-(4-tert-butylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

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Technology Process of 2-[N-(4-tert-butylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

There total 8 articles about 2-[N-(4-tert-butylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 2-amino-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide dihydrochloride

: 98-73-7
4-(1,1-dimethylethyl)benzoic acid

: 1456906-96-9
2-[N-(4-tert-butylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1002/anie.201303999

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 1456906-96-9
2-[N-(4-tert-butylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 13.5 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 13.5 h / 20 °C

3: hydrogenchloride; sodium nitrite; acetic acid / water; acetonitrile / 0 - 20 °C

4: triethylamine; dmap / dichloromethane / 1.5 h / -20 - 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 21.5 h / 40 °C

6: hydrogenchloride / 1,4-dioxane / 0.5 h / 0 - 20 °C

7: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogenchloride; dmap; 5%-palladium/activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201303999

Reference yield:

: 1456905-64-8
2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

: 1456906-96-9
2-[N-(4-tert-butylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 21.5 h / 40 °C

2: hydrogenchloride / 1,4-dioxane / 0.5 h / 0 - 20 °C

3: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201303999