2-(N-tert-butoxycarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide

Base Information

Chemical Name:2-(N-tert-butoxycarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide
CAS No.:1456905-65-9
Molecular Formula:C₂₇H₃₇N₃O₃
Molecular Weight:451.609
Hs Code.:

Synonyms:2-(N-tert-butoxycarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide

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Chemical Property of 2-(N-tert-butoxycarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide

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Technology Process of 2-(N-tert-butoxycarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide

There total 6 articles about 2-(N-tert-butoxycarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1456905-64-8
2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

: (±)-trans-2-phenylcyclopropylamine

: 1456905-65-9
2-(N-tert-butoxycarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 21.5h;

Reference yield: 83.0%

: 1456905-64-8
2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

: 155-09-9
trans-2-phenylcyclopropylamine

: 1456905-65-9
2-(N-tert-butoxycarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 21.5h;
DOI:10.1002/anie.201303999

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 1456905-65-9
2-(N-tert-butoxycarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 13.5 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 13.5 h / 20 °C

3: hydrogenchloride; sodium nitrite; acetic acid / water; acetonitrile / 0 - 20 °C

4: triethylamine; dmap / dichloromethane / 1.5 h / -20 - 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 21.5 h / 40 °C

With hydrogenchloride; dmap; 5%-palladium/activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201303999