[4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methyl 4-fluorobenzenesulfonate

Base Information

• Chemical Name: [4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methyl 4-fluorobenzenesulfonate
• CAS No.: 1222181-59-0
• Molecular Formula: C₁₇H₁₄BrFO₅S
• Molecular Weight: 429.264
• Mol file: 1222181-59-0.mol

Synonyms:[4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methyl 4-fluorobenzenesulfonate

Chemical Property of [4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methyl 4-fluorobenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methyl 4-fluorobenzenesulfonate

There total 1 articles about [4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methyl 4-fluorobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-Fluorobenzenesulfonyl chloride (349-88-2) + 3-(4-bromo-phenyl)-5-hydroxymethyl-dihydro-furan-2-one (362483-77-0) → [4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methyl 4-fluorobenzenesulfonate (1222181-59-0)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.01.030

Reference yield: 85.0%

[4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methyl 4-fluorobenzenesulfonate (1222181-59-0) + methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → methyl 4-{[4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methoxy}benzoate (1222181-66-9)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 70 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.01.030

Reference yield: 78.0%

[4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methyl 4-fluorobenzenesulfonate (1222181-59-0) + methoxymethyl 4-hydroxybenzoate → methoxymethyl 4-{[4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methoxy}benzoate (1222181-60-3)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 70 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.01.030

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

3-(4-bromo-phenyl)-5-hydroxymethyl-dihydro-furan-2-one

Downstream raw materials:

methoxymethyl 3-{[4-(4-bromophenyl)-5-oxotetrahydrofuran-2-yl]methoxy}benzoate

3-(4-bromophenyl)-5-[(3-bromophenoxy)methyl]tetrahydrofuran-2-one

3-(4-bromophenyl)-5-[(4-iodophenoxy)methyl]tetrahydrofuran-2-one

3-(4-bromophenyl)-5-[(4-methoxyphenoxy)methyl]tetrahydrofuran-2-one