3-Bromo-4-iodoisopropylbenzene

Base Information

• Chemical Name: 3-Bromo-4-iodoisopropylbenzene
• CAS No.: 1000578-18-6
• Molecular Formula: C₉H₁₀BrI
• Molecular Weight: 324.987
• Mol file: 1000578-18-6.mol

Synonyms:2-bromo-1-iodo-4-isopropylbenzene

Chemical Property of 3-Bromo-4-iodoisopropylbenzene

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

3-Bromo-4-iodoisopropylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-4-iodoisopropylbenzene

There total 2 articles about 3-Bromo-4-iodoisopropylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-4-isopropylaniline (51605-97-1) → 2-bromo-1-iodo-4-isopropylbenzene (1000578-18-6)

Guidance literature:

2-bromo-4-isopropylaniline; With hydrogenchloride; sodium nitrite;

With potassium iodide;

DOI:10.1039/c4cc01397b

Reference yield:

→ 2-bromo-1-iodo-4-isopropylbenzene (1000578-18-6)

Guidance literature:

Reference yield: 86.0%

2-bromo-1-iodo-4-isopropylbenzene (1000578-18-6) + trimethylsilylacetylene (1066-54-2) → C14H19BrSi (1609556-16-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 23 ℃; for 18h; Inert atmosphere;

DOI:10.1002/anie.202017035

upstream raw materials:

2-bromo-4-isopropylaniline

Downstream raw materials:

4-(2-cyano-4-isopropylphenyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

(2-(hex-1-yn-1-yl)-5-isopropylphenyl)boronic acid

C₁₅H₁₉Br

C₁₄H₁₉BrSi

Refernces

• 1、 Guo, Rui,Li, Kang-Nan,Liu, Bin,Zhu, Hua-Jie,Fan, Yu-Meng,Gong, Liu-Zhu. "Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization-amination cascade reaction". supporting information. p. 5451 - 5454. Retrieved 2014/05/20.