H-Phe-NHTs

Base Information

• Chemical Name: H-Phe-NHTs
• CAS No.: 1619922-33-6
• Molecular Formula: C₁₆H₁₈N₂O₃S
• Molecular Weight: 318.397
• Mol file: 1619922-33-6.mol

Synonyms:H-Phe-NHTs

Chemical Property of H-Phe-NHTs

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-Phe-NHTs

There total 3 articles about H-Phe-NHTs which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-tert-butyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate (1187922-70-8) → H-Phe-NHTs (1619922-33-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2016.02.027

Reference yield:

toluene-4-sulfonamide (70-55-3) → H-Phe-NHTs (1619922-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2016.02.027

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → H-Phe-NHTs (1619922-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2016.02.027

upstream raw materials:

toluene-4-sulfonamide

N-tert-butoxycarbonyl-L-phenylalanine

(S)-tert-butyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate