(S)-tert-butyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate

Base Information

• Chemical Name: (S)-tert-butyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate
• CAS No.: 1187922-70-8
• Molecular Formula: C₂₁H₂₆N₂O₅S
• Molecular Weight: 418.514

Synonyms:(S)-tert-butyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property of (S)-tert-butyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property:

Purity/Quality:

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Technology Process of (S)-tert-butyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate

There total 6 articles about (S)-tert-butyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-toluenesulfonyl azide (941-55-9) + (S)-Se-((9H-fluorenyl)methyl) 2-((tert-butoxycarbonyl)amino)-3-phenylpropaneselenoate (1446274-23-2) → (S)-tert-butyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate (1187922-70-8)

Guidance literature:

(S)-Se-((9H-fluorenyl)methyl) 2-((tert-butoxycarbonyl)amino)-3-phenylpropaneselenoate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; for 0.05h; Inert atmosphere;

4-toluenesulfonyl azide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol401677a

Reference yield:

toluene-4-sulfonamide (70-55-3) + Boc-Phe-O-CO-i-Bu (91127-04-7) → (S)-tert-butyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate (1187922-70-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmc.2015.11.014

Reference yield:

4-toluenesulfonyl azide (941-55-9) + (S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanethioic S-acid (81000-39-7) → (S)-tert-butyl (1-(4-methylphenylsulfonamido)-1-oxo-3-phenylpropan-2-yl)carbamate (1187922-70-8)

Guidance literature:

With 2,6-dimethylpyridine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/ol302247h

upstream raw materials:

4-toluenesulfonyl azide

N-tert-butoxycarbonyl-L-phenylalanine

S-(tert-butyl) (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanethioate

(S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanethioic S-acid

Downstream raw materials:

H-Phe-NHTs

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