6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester

Base Information

Chemical Name:6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester
CAS No.:952206-61-0
Molecular Formula:C₁₅H₁₀Cl₂N₂O₂
Molecular Weight:321.163
Hs Code.:

Synonyms:6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester

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Chemical Property of 6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester

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Technology Process of 6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester

There total 2 articles about 6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 6937-03-7
methyl 2-aminoisonicotinate

: 68716-47-2
2,4-dichlorophenylboronic acid

: 952206-61-0
6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 150 ℃; for 0.283333h; Microwave irradiation;

Reference yield:

: 882499-87-8
methyl 2-amino-5-bromo-pyridine-4-carboxylate

: 952206-61-0
6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / ethanol / 14 h / Heating / reflux

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.28 h / 150 °C / Microwave irradiation

With sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; 2: Suzuki Coupling;

Reference yield: 43.0%

: 952206-61-0
6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester

: 952206-62-1
[6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methanol

Guidance literature:: 6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester; With lithium borohydride; In tetrahydrofuran; methanol; at 0 - 50 ℃; for 4h;

With water; ammonium chloride; In tetrahydrofuran; methanol; at 20 ℃;