6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetonitrile

Base Information

• Chemical Name: 6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetonitrile
• CAS No.: 274264-01-6
• Molecular Formula: C₁₆H₁₂BrN₃
• Molecular Weight: 326.195
• Mol file: 274264-01-6.mol

Synonyms:6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetonitrile

Chemical Property of 6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetonitrile

There total 3 articles about 6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

potassium cyanide (151-50-8) + 6-methyl-2-(4'-bromophenyl)-3-dimethylaminomethylimidazo[1,2-a]pyridinyl methiodide → 6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetonitrile (274264-01-6)

Guidance literature:

In ethanol; water; for 24h; Heating;

DOI:10.1002/(SICI)1099-1344(20000330)43:4<385::AID-JLCR325>3.0.CO;2-K

Reference yield:

6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine (1023-01-4) → 6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetonitrile (274264-01-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / AcOH / H₂O / 24 h / 55 °C

2: 95 percent / benzene / 72 h / 20 °C

3: 70 percent / ethanol; H₂O / 24 h / Heating

With acetic acid; In ethanol; water; benzene; 1: Aminomethylation / 2: Methylation / 3: Substitution;

DOI:10.1002/(SICI)1099-1344(20000330)43:4<385::AID-JLCR325>3.0.CO;2-K

Reference yield:

6-methyl-2-(4'-bromophenyl)-3-dimethylaminomethylimidazo[1,2-a]pyridine (274263-97-7) → 6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetonitrile (274264-01-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / benzene / 72 h / 20 °C

2: 70 percent / ethanol; H₂O / 24 h / Heating

In ethanol; water; benzene; 1: Methylation / 2: Substitution;

DOI:10.1002/(SICI)1099-1344(20000330)43:4<385::AID-JLCR325>3.0.CO;2-K

upstream raw materials:

potassium cyanide

6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine

6-methyl-2-(4'-bromophenyl)-3-dimethylaminomethylimidazo[1,2-a]pyridine

Downstream raw materials:

6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetic acid