S-(+)-2-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-3-(4-hydroxyphenyl)propanoic acid methyl ester

Base Information

• Chemical Name: S-(+)-2-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-3-(4-hydroxyphenyl)propanoic acid methyl ester
• CAS No.: 1220286-46-3
• Molecular Formula: C₂₃H₂₈ClN₅O₅
• Molecular Weight: 489.959
• Mol file: 1220286-46-3.mol

Synonyms:S-(+)-2-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-3-(4-hydroxyphenyl)propanoic acid methyl ester

Chemical Property of S-(+)-2-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-3-(4-hydroxyphenyl)propanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-(+)-2-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-3-(4-hydroxyphenyl)propanoic acid methyl ester

There total 3 articles about S-(+)-2-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-3-(4-hydroxyphenyl)propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.2%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + L-tyrosine methyl ester HCl (3417-91-2) + nitenpiram (150824-47-8) → S-(+)-2-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-3-(4-hydroxyphenyl)propanoic acid methyl ester (1220286-46-3)

Guidance literature:

With triethylamine; In ethanol; at 60 - 75 ℃; Microwave irradiation;

DOI:10.1021/jf904397k

Reference yield:

N-(6-chloro-pyridin-3-yl)methyl-N-ethylamine (120739-77-7) → S-(+)-2-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-3-(4-hydroxyphenyl)propanoic acid methyl ester (1220286-46-3)

Guidance literature:

Multi-step reaction with 3 steps

1: chloroform / 2 - 7 °C

2: 3 - 7 °C

3: triethylamine / ethanol / 60 - 75 °C / Microwave irradiation

With triethylamine; In ethanol; chloroform;

DOI:10.1021/jf904397k

Reference yield:

(E)-N-(6-chloro-3-pyridylmethyl)-N-ethyl-1-chloro-2-nitroethylene-1-amine → S-(+)-2-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-3-(4-hydroxyphenyl)propanoic acid methyl ester (1220286-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 - 7 °C

2: triethylamine / ethanol / 60 - 75 °C / Microwave irradiation

With triethylamine; In ethanol;

DOI:10.1021/jf904397k

upstream raw materials:

formaldehyd

L-tyrosine methyl ester HCl

nitenpiram

N-(6-chloro-pyridin-3-yl)methyl-N-ethylamine