Technology Process of 5-[(3S)-3-phenoxypyrrolidin-1-yl]-2,2-diphenylpentanenitrile
There total 5 articles about 5-[(3S)-3-phenoxypyrrolidin-1-yl]-2,2-diphenylpentanenitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3S)-3-phenoxypyrrolidine hydrochloride; 5-oxo-2,2-diphenylpentanenitrile;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
With
acetic acid;
In
dichloromethane;
at 20 ℃;
for 0.333333h;
Inert atmosphere;
With
sodium tris(acetoxy)borohydride;
In
dichloromethane;
at 20 ℃;
for 5h;
Inert atmosphere;
DOI:10.1021/jm200884j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C / Inert atmosphere
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere
2.2: 18 h / 0 - 20 °C / Inert atmosphere
3.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C / Inert atmosphere
4.1: triethylamine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
4.2: 0.33 h / 20 °C / Inert atmosphere
4.3: 5 h / 20 °C / Inert atmosphere
With
hydrogenchloride; Dess-Martin periodane; triethylamine; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm200884j
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydroxide / methanol; tert-butyl alcohol / 23 h / 20 - 50 °C / Inert atmosphere
2.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C / Inert atmosphere
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere
3.2: 18 h / 0 - 20 °C / Inert atmosphere
4.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
5.2: 0.33 h / 20 °C / Inert atmosphere
5.3: 5 h / 20 °C / Inert atmosphere
With
hydrogenchloride; Dess-Martin periodane; triethylamine; 1,1'-carbonyldiimidazole; potassium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm200884j
