1,3-Bis((benzyloxy)methyl)-6-uracil

Base Information

Chemical Name:1,3-Bis((benzyloxy)methyl)-6-uracil
CAS No.:145744-96-3
Molecular Formula:C₃₁H₃₃N₃O₈
Molecular Weight:575.618
Hs Code.:

1,3-Bis((benzyloxy)methyl)-6-<N-(2,4-dimethoxybenzyl)-N-(carboxymethyl)amino>uracil

Synonyms:1,3-Bis((benzyloxy)methyl)-6-uracil

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Chemical Property of 1,3-Bis((benzyloxy)methyl)-6-uracil

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Technology Process of 1,3-Bis((benzyloxy)methyl)-6-uracil

There total 2 articles about 1,3-Bis((benzyloxy)methyl)-6-uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 145744-96-3
1,3-Bis((benzyloxy)methyl)-6-uracil

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / Heating

2: 1) NaOH, 2) Na₂CO₃ / 1) H₂O, reflux, 1 h, 2) EtOH, reflux, 13.5 h

With sodium hydroxide; sodium carbonate; In benzene;
DOI:10.1021/jo00054a024

Reference yield:

: 95218-34-1
ethyl 2-{[(2,4-dimethoxyphenyl)methyl]amino}acetate

: 145744-95-2
6-Chloro-1,3-bis((benzyloxy)methyl)uracil

: 145744-96-3
1,3-Bis((benzyloxy)methyl)-6-uracil

Guidance literature:: With sodium hydroxide; sodium carbonate; Yield given. Multistep reaction; 1) H₂O, reflux, 1 h, 2) EtOH, reflux, 13.5 h;
DOI:10.1021/jo00054a024

Reference yield:

: 145744-96-3
1,3-Bis((benzyloxy)methyl)-6-uracil

: 145745-02-4
6-(4-(Benzyloxy)benzoyl)-5-(4-(benzyloxy)phenyl)-1,3-bis((benzyloxy)methyl)-2,4-dioxopyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1) 70 deg C, 2 h, 2) reflux, 45 min.

2: 84.6 percent / Na₂CO₃*H₂O / methanol / 0.08 h / Heating

3: 99 percent / 2,4,6-collidine / CH₂Cl₂ / 0.25 h / -78 °C

4: 76.2 percent / ZnCl₂, tri(2-furyl)phosphine / Pd₂dba3 / various solvent(s) / 24 h / 55 °C

5: 1) trifluoroacetic anhydride (TFAA), 2) CF₃COOH / 1) CH₂Cl₂, r.t., 10 min., 2) r.t., 36 h

With 2,4,6-trimethyl-pyridine; trifuran-2-yl-phosphane; sodium carbonate; trifluoroacetic acid; trifluoroacetic anhydride; zinc(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; dichloromethane;
DOI:10.1021/jo00054a024