2-amino-6-bromo-N-(3-bromo-2-(methylcarbamoyl)phenyl)benzamide

Base Information

• Chemical Name: 2-amino-6-bromo-N-(3-bromo-2-(methylcarbamoyl)phenyl)benzamide
• CAS No.: 1447017-92-6
• Molecular Formula: C₁₅H₁₃Br₂N₃O₂
• Molecular Weight: 427.095
• Mol file: 1447017-92-6.mol

Synonyms:2-amino-6-bromo-N-(3-bromo-2-(methylcarbamoyl)phenyl)benzamide

Chemical Property of 2-amino-6-bromo-N-(3-bromo-2-(methylcarbamoyl)phenyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-6-bromo-N-(3-bromo-2-(methylcarbamoyl)phenyl)benzamide

There total 1 articles about 2-amino-6-bromo-N-(3-bromo-2-(methylcarbamoyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-amino-6-chlorobenzoic acid (20776-48-1) + methylamine (74-89-5) → 2-amino-6-bromo-N-(3-bromo-2-(methylcarbamoyl)phenyl)benzamide (1447017-92-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; at 20 ℃;

DOI:10.1016/j.cclet.2013.04.047

Reference yield: 64.0%

2-amino-6-bromo-N-(3-bromo-2-(methylcarbamoyl)phenyl)benzamide (1447017-92-6) + phenylmethanethiol (100-53-8) → 2-amino-N-(3-(benzylthio)-2-(methylcarbamoyl)phenyl)-6-bromobenzamide (1447017-93-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.cclet.2013.04.047

Reference yield:

2-amino-6-bromo-N-(3-bromo-2-(methylcarbamoyl)phenyl)benzamide (1447017-92-6) → 2-(benzylthio)-6-(2-bromo-6-(4-chlorobenzamido)benzamido)-N-methylbenzamide (1447017-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.cclet.2013.04.047

upstream raw materials:

2-amino-6-chlorobenzoic acid

methylamine

Downstream raw materials:

2-amino-N-(3-(benzylthio)-2-(methylcarbamoyl)phenyl)-6-bromobenzamide

N-(2-((3-(benzylsulfinyl)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-2-bromo-3-nitrobenzamide

2-(benzylthio)-6-(2-bromo-6-(4-cyano-3-fluorobenzamido)benzamido)-N-methylbenzamide

N-(2-((3-(benzylthio)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-2-bromo-3-nitrobenzamide