trans-(1R)-2-<<(1,1,-dimethylethyl)dimethylsilyl>oxy>-4-methylenecyclohexanemethanol

Base Information

Chemical Name:trans-(1R)-2-<<(1,1,-dimethylethyl)dimethylsilyl>oxy>-4-methylenecyclohexanemethanol
CAS No.:145668-37-7
Molecular Formula:C₁₄H₂₈O₂Si
Molecular Weight:256.461
Hs Code.:

Synonyms:trans-(1R)-2-<<(1,1,-dimethylethyl)dimethylsilyl>oxy>-4-methylenecyclohexanemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-(1R)-2-<<(1,1,-dimethylethyl)dimethylsilyl>oxy>-4-methylenecyclohexanemethanol

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Technology Process of trans-(1R)-2-<<(1,1,-dimethylethyl)dimethylsilyl>oxy>-4-methylenecyclohexanemethanol

There total 3 articles about trans-(1R)-2-<<(1,1,-dimethylethyl)dimethylsilyl>oxy>-4-methylenecyclohexanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 145668-36-6
trans-(1S)-2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-methylenecyclohexanecarboxylic acid methyl ester

: 145668-37-7
trans-(1R)-2-<<(1,1,-dimethylethyl)dimethylsilyl>oxy>-4-methylenecyclohexanemethanol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; for 0.25h; -50 deg C to 0 deg C;
DOI:10.1021/jo00056a013

Reference yield:

: 1779-49-3
Methyltriphenylphosphonium bromide

: 145668-37-7
trans-(1R)-2-<<(1,1,-dimethylethyl)dimethylsilyl>oxy>-4-methylenecyclohexanemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) potassium tert-butoxide / 1.) THF, 2.) THF, r.t., 20 min

2: 86 percent / DIBAL-H / CH₂Cl₂ / 0.25 h / -50 deg C to 0 deg C

With potassium tert-butylate; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1021/jo00056a013

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 145668-37-7
trans-(1R)-2-<<(1,1,-dimethylethyl)dimethylsilyl>oxy>-4-methylenecyclohexanemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) potassium tert-butoxide / 1.) THF, 2.) THF, r.t., 20 min

2: 86 percent / DIBAL-H / CH₂Cl₂ / 0.25 h / -50 deg C to 0 deg C

With potassium tert-butylate; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1021/jo00056a013