6-(hydroxy(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methyl)-3-phenyl-2-(trifluoromethyl)quinoline-4-carbonitrile trifluoroacetate

Base Information

Chemical Name:6-(hydroxy(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methyl)-3-phenyl-2-(trifluoromethyl)quinoline-4-carbonitrile trifluoroacetate
CAS No.:1600565-47-6
Molecular Formula:C₂HF₃O₂*C₂₇H₁₈F₃N₅O
Molecular Weight:599.492
Hs Code.:

Synonyms:6-(hydroxy(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methyl)-3-phenyl-2-(trifluoromethyl)quinoline-4-carbonitrile trifluoroacetate

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Chemical Property of 6-(hydroxy(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methyl)-3-phenyl-2-(trifluoromethyl)quinoline-4-carbonitrile trifluoroacetate

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Technology Process of 6-(hydroxy(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methyl)-3-phenyl-2-(trifluoromethyl)quinoline-4-carbonitrile trifluoroacetate

There total 5 articles about 6-(hydroxy(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methyl)-3-phenyl-2-(trifluoromethyl)quinoline-4-carbonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1600565-41-0
(4-chloro-3-phenyl-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol trifluoroacetate

: 1600565-47-6
6-(hydroxy(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methyl)-3-phenyl-2-(trifluoromethyl)quinoline-4-carbonitrile trifluoroacetate

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In N,N-dimethyl acetamide; at 120 ℃; for 5h; Sealed tube; Inert atmosphere;

Reference yield:

: 5326-47-6
2-amino-5-iodobenzoic acid

: 1600565-47-6
6-(hydroxy(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methyl)-3-phenyl-2-(trifluoromethyl)quinoline-4-carbonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Eaton’s reagent / dichloromethane / 4 h / 100 °C / Sealed tube

2.1: trichlorophosphate / 1.75 h / 110 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.38 h / -78 °C

3.2: 20 - 50 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 5 h / 120 °C / Sealed tube; Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Eaton’s reagent; isopropylmagnesium chloride; zinc; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 350-92-5
1,1,1-Trifluoro-3-phenylpropan-2-one

: 1600565-47-6
6-(hydroxy(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methyl)-3-phenyl-2-(trifluoromethyl)quinoline-4-carbonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Eaton’s reagent / dichloromethane / 4 h / 100 °C / Sealed tube

2.1: trichlorophosphate / 1.75 h / 110 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.38 h / -78 °C

3.2: 20 - 50 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 5 h / 120 °C / Sealed tube; Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Eaton’s reagent; isopropylmagnesium chloride; zinc; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;