Technology Process of 2-[(2R,3S)-1-benzyl-3-(methoxymethoxy)-2,3,4,7-tetrahydro-1H-azepin-2-yl]ethanol
There total 7 articles about 2-[(2R,3S)-1-benzyl-3-(methoxymethoxy)-2,3,4,7-tetrahydro-1H-azepin-2-yl]ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Grubbs catalyst first generation;
In
chloroform;
at 60 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1016/j.ejmech.2014.01.036
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 100 °C
1.2: 2.5 h / 0 - 20 °C
2.1: Grubbs catalyst first generation / chloroform / 2.5 h / 60 °C / Inert atmosphere
With
Grubbs catalyst first generation; sodium hydride;
In
chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2014.01.036
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C
1.2: 0 °C
2.1: tetrahydrofuran / 2 h / -78 - 0 °C
3.1: diisopropylamine; potassium iodide / 1,2-dimethoxyethane / 4 h / Reflux
4.1: ammonium cerium (IV) nitrate / dichloromethane; acetonitrile / 0.5 h / 20 °C
5.1: 1H-imidazole / dichloromethane / 2.5 h / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 100 °C
6.2: 2.5 h / 0 - 20 °C
7.1: Grubbs catalyst first generation / chloroform / 2.5 h / 60 °C / Inert atmosphere
With
1H-imidazole; Grubbs catalyst first generation; ammonium cerium (IV) nitrate; oxalyl dichloride; sodium hydride; diisopropylamine; potassium iodide;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.ejmech.2014.01.036
![(3R,4S)-3-[allyl(benzyl)amino]-4-(methoxymethoxy)hept-6-en-1-ol](/Databaselist/images/loading.webp)
