(2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol

Base Information

• Chemical Name: (2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol
• CAS No.: 616890-44-9
• Molecular Formula: C₂₄H₃₇NO₂Si
• Molecular Weight: 399.649
• Mol file: 616890-44-9.mol

Synonyms:(2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol

Chemical Property of (2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol

There total 3 articles about (2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

tert-butyldimethylsilyl chloride (18162-48-6) + (R)-2-Dibenzylamino-butane-1,4-diol (908598-98-1) → (2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol (616890-44-9)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 ℃;

DOI:10.1021/jm0601809

Reference yield:

(R)-2-Dibenzylamino-succinic acid → (2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol (616890-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 0 °C

2: 42 percent / imidazole / CH₂Cl₂ / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0601809

Reference yield:

benzyl bromide (100-39-0) → (2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol (616890-44-9)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃; NaOH / methanol; H₂O / Heating

2: LiAlH₄ / tetrahydrofuran / 0 °C

3: 42 percent / imidazole / CH₂Cl₂ / 0 °C

With 1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/jm0601809

upstream raw materials:

tert-butyldimethylsilyl chloride

(R)-2-Dibenzylamino-butane-1,4-diol

benzyl bromide

Downstream raw materials:

(3R,4S)-3-(benzylamino)-4-(methoxymethoxy)hept-6-en-1-ol

(3R,4S)-N,N-dibenzyl-1-(tert-butyldimethylsilyloxy)-4-(methoxymethoxy)hept-6-en-3-amine

(4S,5R)-7-(tert-butyldimethylsilyloxy)-5-(dibenzylamino)hept-1-en-4-ol

C₂₉H₄₇NO₅Si