N-ethoxycarbonyl 1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)pyridine

Base Information

• Chemical Name: N-ethoxycarbonyl 1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)pyridine
• CAS No.: 1600518-01-1
• Molecular Formula: C₂₃H₂₂N₂O₄S
• Molecular Weight: 422.505
• Mol file: 1600518-01-1.mol

Synonyms:N-ethoxycarbonyl 1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)pyridine

Chemical Property of N-ethoxycarbonyl 1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-ethoxycarbonyl 1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)pyridine

There total 3 articles about N-ethoxycarbonyl 1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

pyridine (110-86-1) + chloroformic acid ethyl ester (541-41-3) + N-ethynyl-N-phenyl-4-methyl-benzenesulfonamide (312329-87-6) → N-ethoxycarbonyl 1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)pyridine (1600518-01-1)

Guidance literature:

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 2.5h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo500365h

Reference yield:

phenyl toluenesulfonamide (68-34-8) → N-ethoxycarbonyl 1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)pyridine (1600518-01-1)

Guidance literature:

Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide

2: triphenylphosphine

3: n-butyllithium

4: copper(l) iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 25 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In dichloromethane;

DOI:10.1021/jo500365h

Reference yield:

N-Formyl-N-phenyl-4-methyl-benzenesulfonamide (68984-88-3) → N-ethoxycarbonyl 1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)pyridine (1600518-01-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine

2: n-butyllithium

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 25 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane;

DOI:10.1021/jo500365h

upstream raw materials:

pyridine

chloroformic acid ethyl ester

N-ethynyl-N-phenyl-4-methyl-benzenesulfonamide

phenyl toluenesulfonamide