Benzoic acid (2S,4S)-4-[2,4-dioxo-5-((E)-2-trimethylsilanyl-vinyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl ester

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Chemical Name:Benzoic acid (2S,4S)-4-[2,4-dioxo-5-((E)-2-trimethylsilanyl-vinyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl ester
CAS No.:1053401-71-0
Molecular Formula:C₂₁H₂₆N₂O₅Si
Molecular Weight:414.533
Hs Code.:

Synonyms:Benzoic acid (2S,4S)-4-[2,4-dioxo-5-((E)-2-trimethylsilanyl-vinyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of Benzoic acid (2S,4S)-4-[2,4-dioxo-5-((E)-2-trimethylsilanyl-vinyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl ester

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Technology Process of Benzoic acid (2S,4S)-4-[2,4-dioxo-5-((E)-2-trimethylsilanyl-vinyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl ester

There total 7 articles about Benzoic acid (2S,4S)-4-[2,4-dioxo-5-((E)-2-trimethylsilanyl-vinyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4105-29-7
[(3aR,5S,6aR)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate

: 1053401-71-0
Benzoic acid (2S,4S)-4-[2,4-dioxo-5-((E)-2-trimethylsilanyl-vinyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃SiH; BF₃*Et₂O / CH₂Cl₂

2: Et₃N / CH₂Cl₂

3: NaN₃ / dimethylformamide / 55 °C

4: H₂ / Pd/C / ethanol; ethyl acetate

5: toluene

6: H₂SO₄ / dioxane / 100 °C

7: ICl / CH₂Cl₂

8: (Ph₃P)2Pd(II)Cl₂ / acetonitrile / 50 °C

With triethylsilane; bis-triphenylphosphine-palladium(II) chloride; sodium azide; sulfuric acid; boron trifluoride diethyl etherate; hydrogen; Iodine monochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm025569k

Reference yield:

: 143191-75-7
2(S)-(O-benzoylmethyl)tetrahydrofuran-4(R)-ol

: 1053401-71-0
Benzoic acid (2S,4S)-4-[2,4-dioxo-5-((E)-2-trimethylsilanyl-vinyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂

2: NaN₃ / dimethylformamide / 55 °C

3: H₂ / Pd/C / ethanol; ethyl acetate

4: toluene

5: H₂SO₄ / dioxane / 100 °C

6: ICl / CH₂Cl₂

7: (Ph₃P)2Pd(II)Cl₂ / acetonitrile / 50 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium azide; sulfuric acid; hydrogen; Iodine monochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm025569k

Reference yield:

: 160999-11-1
4(S)-azido-2(S)-(O-benzoylmethyl)tetrahydrofuran

: 1053401-71-0
Benzoic acid (2S,4S)-4-[2,4-dioxo-5-((E)-2-trimethylsilanyl-vinyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / ethanol; ethyl acetate

2: toluene

3: H₂SO₄ / dioxane / 100 °C

4: ICl / CH₂Cl₂

5: (Ph₃P)2Pd(II)Cl₂ / acetonitrile / 50 °C

With bis-triphenylphosphine-palladium(II) chloride; sulfuric acid; hydrogen; Iodine monochloride; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jm025569k