143191-75-7

Upstream product

• 4105-29-7 [(3aR,5S,6aR)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 20881-04-3 1,2:3,5-di-O-isopropylidene-D-xylofuranose 
• 6022-96-4 5-O-benzoyl-α-D-xylofuranose 
• 160999-15-5 5-O-benzoyl-3-O-(1-imidazolylthiocarbonyl)-1,2-O-isopropylidene-α-D-xylofuranose 
• 98-88-4 benzoyl chloride 
• 532-20-7 D-xylofuranose 
• 143191-74-6 methyl 5-O-benzoyl-3-deoxy-D-erythro-pentofuranose 

Downstream Products

• 160999-09-7 2(S)-(O-benzoylmethyl)-4(S)-(6-cyclopropylamino-9H-purin-9-yl)tetrahydrofuran 
• 160999-07-5 4(S)-(2-amino-6-chloro-9H-purin-9-yl)-2(S)-(O-benzoylmethyl)tetrahydrofuran 
• 160999-14-4 4(S)-<3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl>-2(S)-(p-O-toluenesulfonylmethyl)tetrahydrofuran 
• 151223-88-0 2(S)-(O-benzoylmethyl)-4(S)-(6-chloro-9H-purin-9-yl)tetrahydrofuran 
• 160999-12-2 N-<<<(2S,4S)-2-(O-benzoylmethyl)tetrahydrofuranyl>amino>carbonyl>-3-ethoxy-2-propenamide 
• 151223-91-5 2(S)-(O-benzoylmethyl)-4(S)-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>tetrahydrofuran 
• 143191-79-1 2(S)-(O-benzoylmethyl)-4(S)-<3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl>tetrahydrofuran 
• 143191-80-4 2(S)-(O-benzoylmethyl)-4(S)-<4-(1,2,4-triazolyl)-2-oxo-1(2H)-pyrimidinyl>tetrahydrofuran 
• 151223-92-6 4(S)-<4-amino-2-oxo-1(2H)-pyrimidinyl>-2(S)-(O-benzoylmethyl)tetrahydrofuran 
• 151223-87-9 4(S)-(6-amino-9H-purin-9-yl)-2(S)-(O-benzoylmethyl)tetrahydrofuran 
• 143191-83-7 1-[(3S,5S)-5-(hydroxymethyl)tetrahydrofuran-3-yl]thymine 
• 151223-91-5 4(S)-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate 
• 143191-76-8 1,4-anhydro-5-O-benzoyl-3-deoxy-2-O-p-toluenesulfonyl-D-ribitol 
• 1053401-71-0 Benzoic acid (2S,4S)-4-[2,4-dioxo-5-((E)-2-trimethylsilanyl-vinyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

An improved method for the synthesis of anhydroalditols

An improved synthesis of anhydroalditols through reductive cleavage of acetylated carbohydrates is reported. The procedure appears to have generality. Ring rearrangements, which complicate some other reported procedures for the preparation of anhydroaldit

A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity

(E)-5-(2-Bromovinyl)isodideoxyuridine (BVisoDDU), synthesized on the basis of molecular modeling, is selectively active against HSV-1 (three different strains) but inactive against HSV-2. Unlike BVDU, BVisoDDU is completely resistant to cleavage by thymidine phosphorylase. BVisoDDU is also the first nucleoside analogue lacking OH groups at both the 2′- and 3′-position that shows pronounced activity against HSV-1 replication.

Novel isomeric dideoxynucleosides as potential antiviral agents

Novel isomeric dideoxynucleosides with S,S absolute stereochemistry and involving the transposition of the base moiety from the normal 1'- to the 2'-position have been regiospecifically and stereospecifically synthesized. The synthetic approaches involved

THE SYNTHESIS OF (S) AND (R) ENANTIOMERS OF NOVEL HYDROXYMETHYLATED ISODIDEOXYNUCLEOSIDES

Novel isomeric dideoxynucleosides, with symmetry introduced at the 2'-position (4'-position using normal nucleoside numbernig) through the introduction of an additional hydroxymethyl group, have been synthesized.Both (R) and (S) enantiomeric series were investigated.The methodologies developed have generality and the presence of the hydroxymethyl group trans to the base may be used to introduce a wide variety of functionalities at this position.