(+/-)-1-O-tert-butyldiphenylsilyl-5-O-pivaloylpentane-1,3,5-triol

Base Information

• Chemical Name: (+/-)-1-O-tert-butyldiphenylsilyl-5-O-pivaloylpentane-1,3,5-triol
• CAS No.: 889886-06-0
• Molecular Formula: C₂₆H₃₈O₄Si
• Molecular Weight: 442.671
• Mol file: 889886-06-0.mol

Synonyms:(+/-)-1-O-tert-butyldiphenylsilyl-5-O-pivaloylpentane-1,3,5-triol

Chemical Property of (+/-)-1-O-tert-butyldiphenylsilyl-5-O-pivaloylpentane-1,3,5-triol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-1-O-tert-butyldiphenylsilyl-5-O-pivaloylpentane-1,3,5-triol

There total 4 articles about (+/-)-1-O-tert-butyldiphenylsilyl-5-O-pivaloylpentane-1,3,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-5-O-pivaloylpentane-1,3,5-triol (889886-05-9) + tert-butylchlorodiphenylsilane (58479-61-1) → (+/-)-1-O-tert-butyldiphenylsilyl-5-O-pivaloylpentane-1,3,5-triol (889886-06-0)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1080/15257770500265612

Reference yield:

(+/-)-1-O-pivaloyl-3,5-O-isopropylidenepentane-1,3,5-triol (889886-04-8) → (+/-)-1-O-tert-butyldiphenylsilyl-5-O-pivaloylpentane-1,3,5-triol (889886-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / H₂O / 15 h / 50 - 55 °C

2: 13 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; acetic acid; In dichloromethane; water;

DOI:10.1080/15257770500265612

Reference yield:

pivaloyl chloride (3282-30-2) → (+/-)-1-O-tert-butyldiphenylsilyl-5-O-pivaloylpentane-1,3,5-triol (889886-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 17 h / 20 °C

2: AcOH / H₂O / 15 h / 50 - 55 °C

3: 13 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

With pyridine; 1H-imidazole; acetic acid; In dichloromethane; water;

DOI:10.1080/15257770500265612

upstream raw materials:

(+/-)-5-O-pivaloylpentane-1,3,5-triol

tert-butylchlorodiphenylsilane

(+/-)-1-O-pivaloyl-3,5-O-isopropylidenepentane-1,3,5-triol

pivaloyl chloride

Downstream raw materials:

(+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-pivaloyloxy)propyl]adenine

(+/-)-9-[(1-tert-butyldiphenylsilyloxyethyl)(3-hydroxy)propyl]adenine

(+/-)-9-[(1-trityloxyethyl)(3-hydroxy)propyl]-N⁶-trityladenine

(+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N⁶-trityladenine