methyl-6-[2-(hydroxymethyl)-3-methoxyphenyl]hexanoate

Base Information

• Chemical Name: methyl-6-[2-(hydroxymethyl)-3-methoxyphenyl]hexanoate
• CAS No.: 197708-04-6
• Molecular Formula: C₁₅H₂₂O₄
• Molecular Weight: 266.337
• Mol file: 197708-04-6.mol

Synonyms:methyl-6-[2-(hydroxymethyl)-3-methoxyphenyl]hexanoate

Chemical Property of methyl-6-[2-(hydroxymethyl)-3-methoxyphenyl]hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl-6-[2-(hydroxymethyl)-3-methoxyphenyl]hexanoate

There total 6 articles about methyl-6-[2-(hydroxymethyl)-3-methoxyphenyl]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6-[2-(hydroxymethyl)-3-methoxyphenyl]-(5E)-hexenoate (134577-97-2) → methyl-6-[2-(hydroxymethyl)-3-methoxyphenyl]hexanoate (197708-04-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 25 ℃; for 1h; under 760 Torr; Yield given;

DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

3-hydroxyphthalic anhydride (37418-88-5) → methyl-6-[2-(hydroxymethyl)-3-methoxyphenyl]hexanoate (197708-04-6)

Guidance literature:

Multi-step reaction with 6 steps

2: 37 percent / NaBH₄ / acetic acid; tetrahydrofuran / 2 h / 50 °C

3: 100 percent / DIBAH / toluene / 0.5 h / -70 °C

4: 1.) t-BuOK / 1.) 80 deg C, 1.5 h, 2.) toluene, 1.5 h

5: ethyl acetate / 0.17 h / 0 °C

6: H₂ / 5percent Pd/C / ethanol / 1 h / 25 °C / 760 Torr

With sodium tetrahydroborate; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; ethyl acetate; toluene;

DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

3-methoxyphthalic anhydride (14963-96-3) → methyl-6-[2-(hydroxymethyl)-3-methoxyphenyl]hexanoate (197708-04-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 37 percent / NaBH₄ / acetic acid; tetrahydrofuran / 2 h / 50 °C

2: 100 percent / DIBAH / toluene / 0.5 h / -70 °C

3: 1.) t-BuOK / 1.) 80 deg C, 1.5 h, 2.) toluene, 1.5 h

4: ethyl acetate / 0.17 h / 0 °C

5: H₂ / 5percent Pd/C / ethanol / 1 h / 25 °C / 760 Torr

With sodium tetrahydroborate; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; ethyl acetate; toluene;

DOI:10.1016/S0968-0896(97)00089-8

upstream raw materials:

methyl 6-[2-(hydroxymethyl)-3-methoxyphenyl]-(5E)-hexenoate

3-hydroxyphthalic anhydride

3-methoxyphthalic anhydride

(4-carboxybutyl)triphenylphosphonium bromide

Downstream raw materials:

ethyl-6-{2-[2-(ethoxycarbonyl)ethyl]-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}hexanoate

Ethyl 6-[2-(2-ethoxycarbonylethyl)-3-hydroxyphenyl]hexanoate

Methyl 6-[2-(2-ethoxycarbonylethyl)-3-metoxyphenyl]hexanoate

methyl-6-{2-[2-(ethoxycarbonyl)-(E)-ethenyl]-3-methoxyphenyl}hexanoate