14963-96-3

Basic information

• Product Name: 1,3-Isobenzofurandione,4-methoxy-(9CI)
• Synonyms: 1,3-Isobenzofurandione,4-methoxy-(9CI);4-Methoxy-1,3-isobenzofurandione;NSC 239373
• CAS NO: 14963-96-3
• Molecular Formula: C₉H₆O₄
• Molecular Weight: 178.14154
• Product Categories: PHENYL
• Mol File: 14963-96-3.mol

Chemical Properties

• Boiling Point: 351.9°Cat760mmHg
• Flash Point: 160.6°C
• Appearance: /
• Density: 1.407g/cm³
• Vapor Pressure: 3.97E-05mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1,3-Isobenzofurandione,4-methoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Isobenzofurandione,4-methoxy-(9CI)(14963-96-3)
• EPA Substance Registry System: 1,3-Isobenzofurandione,4-methoxy-(9CI)(14963-96-3)

Safety Data

• Hazardous Substances Data: 14963-96-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,3-Isobenzofurandione,4-methoxy-(9CI) is used as a reactant for the preparation of potent nonpeptide angiotensin II receptor antagonists. These antagonists play a crucial role in the treatment of hypertension and heart failure by blocking the effects of angiotensin II, a potent vasoconstrictor. The compound's unique structure allows for the development of effective and selective angiotensin II receptor blockers, which can help in managing blood pressure and improving cardiovascular health.

InChI:InChI=1/C9H6O4/c1-12-6-4-2-3-5-7(6)9(11)13-8(5)10/h2-4H,1H3

Upstream product

• 2944-49-2 2,3-dimethylanisole 
• 124-38-9 carbon dioxide 
• 62924-93-0 N,N-diethyl-3-methoxybenzamide 

Downstream Products

• 147666-87-3 7-methoxy-3-((Ξ)-veratrylidene)-phthalide 
• 108838-48-8 2-(2-hydroxy-4-methyl-benzoyl)-3-methoxy-benzoic acid 
• 41709-83-5 4-methoxy-isoindole-1,3-dione 
• 4792-33-0 4-methoxyphthalide 
• 28281-58-5 7-methoxyisobenzofuran-1(3H)-one 
• 90047-52-2 3-methoxy-o-xylene-α,α'-diol 
• 68409-21-2 2-(2,5-Dimethoxy-4-methylbenzoyl)-3-methoxybenzoesaeure-methylester 
• 68409-20-1 6-(2,5-Dimethoxy-4-methylbenzoyl)-2-methoxybenzoesaeure-methylester 
• 68409-22-3 3-(2,5-Dimethoxy-3-methylphenyl)-3-hydroxy-7-methoxy-1(3H)-isobenzofuranon 
• 51837-72-0 2-(2,5-dimethoxy-4-methylbenzoyl)-3-methoxybenzoic acid 
• 68409-19-8 3-(2,5-Dimethoxy-4-methylphenyl)-3-hydroxy-7-methoxy-1(3H)-isobenzofuranon 
• 57996-21-1 7-methoxy-3-phenylisobenzofuran-1(3H)-one 
• 96597-77-2 3-Hydroxy-7-methoxy-3-phenyl-1(3H)-isobenzofuranon 
• 121364-88-3 3-(2,5-dimethoxyphenyl)-3-hydroxy-4-methoxy-1(3H)-isobenzofuranone 

Relevant articles and documents

Insecticidal Benzenedicarboxamide Derivative

The present invention relates to a novel benzenedicarboxamide derivative and the use thereof as an insecticide having the formula (I) wherein the chemical groups W1 to W9, and R1 to R3 are as defined here-in.

Directed ortho metalation of n,n-diethyl benzamides. Methodology and regiospecific synthesis of useful contiguously tri- and tetra-substituted oxygenated aromatics, phthalides and phthalic anhydrides

Full experimental details for the directed ortho metalation approch to a variety of simple ortho-substituted N,N-diethyl benzamides (Table 1) and contiguously 1,2,3- and 1,2,3,4-substituted benzamides (Tables 2) are given. The efficient conversion of these benzamides (6, 10, 12, 13, 18, 19) into phthalides (9a-b, 16b-c, 17) and phthalic anhydrides (8,16a), compounds previously available by demanding, classical methods, is detailed. A short synthesis of iso-ochracinic acid (27) is described.