((S)-2,4-dimethyl-piperazin-1-yl)-{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-methanone

Base Information

Chemical Name:((S)-2,4-dimethyl-piperazin-1-yl)-{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-methanone
CAS No.:1431541-97-7
Molecular Formula:C₂₇H₂₇N₅O₂
Molecular Weight:453.544
Hs Code.:

Synonyms:((S)-2,4-dimethyl-piperazin-1-yl)-{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-methanone

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Chemical Property of ((S)-2,4-dimethyl-piperazin-1-yl)-{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-methanone

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Technology Process of ((S)-2,4-dimethyl-piperazin-1-yl)-{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-methanone

There total 8 articles about ((S)-2,4-dimethyl-piperazin-1-yl)-{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1431541-96-6
{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone

: 1431541-97-7
((S)-2,4-dimethyl-piperazin-1-yl)-{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-methanone

Guidance literature:: formaldehyd; {3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 2h;

Reference yield:

: 1431542-29-8
3-(6-bromo-quinazolin-4-yl)-benzoic acid ethyl ester

: 1431541-97-7
((S)-2,4-dimethyl-piperazin-1-yl)-{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.25 h / 120 °C / Microwave irradiation; Inert atmosphere

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.33 h / 20 °C

3.2: 2 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: methanol / 0.5 h / 20 °C

5.2: 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1431542-43-6
3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-benzoic acid ethyl ester

: 1431541-97-7
((S)-2,4-dimethyl-piperazin-1-yl)-{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 4 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.33 h / 20 °C

2.2: 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: methanol / 0.5 h / 20 °C

4.2: 2 h / 20 °C

With lithium hydroxide monohydrate; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane;