(S)-methyl N-methyl-4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbimidothioate hydroiodide

Base Information

Chemical Name:(S)-methyl N-methyl-4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbimidothioate hydroiodide
CAS No.:1415797-60-2
Molecular Formula:C₂₁H₂₆N₆O₃S*HI
Molecular Weight:570.454
Hs Code.:

Synonyms:(S)-methyl N-methyl-4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbimidothioate hydroiodide

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Chemical Property of (S)-methyl N-methyl-4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbimidothioate hydroiodide

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Technology Process of (S)-methyl N-methyl-4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbimidothioate hydroiodide

There total 2 articles about (S)-methyl N-methyl-4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbimidothioate hydroiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1415797-59-9
(S)-N-methyl-4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbothioamide

: 74-88-4
methyl iodide

: 1415797-60-2
(S)-methyl N-methyl-4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbimidothioate hydroiodide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/ml3003132

Reference yield:

: 1207369-02-5
(S)-3-methyl-4-(2-(4-nitrophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)morpholine

: 1415797-60-2
(S)-methyl N-methyl-4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbimidothioate hydroiodide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

In N,N-dimethyl-formamide;
DOI:10.1021/ml3003132

Reference yield:

: 1415797-60-2
(S)-methyl N-methyl-4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbimidothioate hydroiodide

: 645-36-3
2,2-diethoxy-ethanamine

: 1415797-61-3
(S)-3-methyl-4-(7-(1-methyl-1H-imidazol-2-yl)-2-(4-nitrophenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)morpholine

Guidance literature:: (S)-methyl N-methyl-4-(3-methylmorpholino)-2-(4-nitrophenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbimidothioate hydroiodide; 2,2-diethoxy-ethanamine; In pyridine; at 115 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In water; for 1h; Reflux; Inert atmosphere;
DOI:10.1021/ml3003132