ethyl (R)-2-(benzyloxy)-2-[(4'R)-2',2'-dimethyl-1',3'-dioxolan-4'-yl]acetate

Base Information

• Chemical Name: ethyl (R)-2-(benzyloxy)-2-[(4'R)-2',2'-dimethyl-1',3'-dioxolan-4'-yl]acetate
• CAS No.: 287119-15-7
• Molecular Formula: C₁₆H₂₂O₅
• Molecular Weight: 294.348
• Mol file: 287119-15-7.mol

Synonyms:ethyl (R)-2-(benzyloxy)-2-[(4'R)-2',2'-dimethyl-1',3'-dioxolan-4'-yl]acetate

Chemical Property of ethyl (R)-2-(benzyloxy)-2-[(4'R)-2',2'-dimethyl-1',3'-dioxolan-4'-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl (R)-2-(benzyloxy)-2-[(4'R)-2',2'-dimethyl-1',3'-dioxolan-4'-yl]acetate

There total 1 articles about ethyl (R)-2-(benzyloxy)-2-[(4'R)-2',2'-dimethyl-1',3'-dioxolan-4'-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl (R)-2-[(4'R)-2',2'-dimethyl-1,3-dioxolan-4'-yl]-2-hydroxyacetate (114184-94-0) + benzyl bromide (100-39-0) → ethyl (R)-2-(benzyloxy)-2-[(4'R)-2',2'-dimethyl-1',3'-dioxolan-4'-yl]acetate (287119-15-7)

Guidance literature:

With silver(l) oxide; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.carres.2016.09.010

Reference yield: 100.0%

ethyl (R)-2-(benzyloxy)-2-[(4'R)-2',2'-dimethyl-1',3'-dioxolan-4'-yl]acetate (287119-15-7) → 1-O-benzyl-3,4-O-isopropylidene-D-erythritol (12) and 2-O-benzyl-3,4-O-isopropylidene-D-erythritol (111462-38-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1002/(SICI)1522-2675(20000510)83:5<943::AID-HLCA943>3.0.CO;2-H

Reference yield: 97.0%

ethyl (R)-2-(benzyloxy)-2-[(4'R)-2',2'-dimethyl-1',3'-dioxolan-4'-yl]acetate (287119-15-7) → (R)-2-(benzyloxy)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde (103795-12-6)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.25h;

DOI:10.1002/1099-0690(200111)2001:21<4111::AID-EJOC4111>3.0.CO;2-7

upstream raw materials:

ethyl (R)-2-[(4'R)-2',2'-dimethyl-1,3-dioxolan-4'-yl]-2-hydroxyacetate

benzyl bromide

Downstream raw materials:

1-O-benzyl-3,4-O-isopropylidene-D-erythritol ⁽¹²⁾ and 2-O-benzyl-3,4-O-isopropylidene-D-erythritol

(R)-2-(benzyloxy)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde

(6R,7R,8S)-7,8-Bis-benzyloxy-5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-6-ol

(6R,7R,8R)-7,8-Bis-benzyloxy-5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-6-ol