3-(1-cyano-4-hydroxy-6-(o-tolyloxy)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Base Information

Chemical Name:3-(1-cyano-4-hydroxy-6-(o-tolyloxy)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid
CAS No.:1455090-26-2
Molecular Formula:C₂₃H₂₁N₃O₅
Molecular Weight:419.437
Hs Code.:

Synonyms:3-(1-cyano-4-hydroxy-6-(o-tolyloxy)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

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Chemical Property of 3-(1-cyano-4-hydroxy-6-(o-tolyloxy)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

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Technology Process of 3-(1-cyano-4-hydroxy-6-(o-tolyloxy)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

There total 12 articles about 3-(1-cyano-4-hydroxy-6-(o-tolyloxy)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392841-25-6
3-amino-2,2-dimethylpropionic acid TFA salt

: 1455094-65-1
butyl 1-cyano-4-hydroxy-6-(o-tolyloxy)isoquinoline-3-carboxylate

: 1455090-26-2
3-(1-cyano-4-hydroxy-6-(o-tolyloxy)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Guidance literature:: With sodium methylate; In ethanol; at 150 ℃; for 1.5h; Microwave irradiation;

Reference yield:

: 1572-98-1
2-cyano-2-methyl-propionic acid ethyl ester

: 1455090-26-2
3-(1-cyano-4-hydroxy-6-(o-tolyloxy)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / ethanol / 20 h / 20 °C

2: sodium hydroxide / methanol; water / 6 h / 20 °C

3: dichloromethane / 3 h / 20 °C

4: sodium methylate / ethanol / 1.5 h / 150 °C / Microwave irradiation

With hydrogen; sodium methylate; sodium hydroxide; In methanol; ethanol; dichloromethane; water;

Reference yield:

: 59193-77-0
3-amino-2,2-dimethylpropionic acid ethyl ester

: 1455090-26-2
3-(1-cyano-4-hydroxy-6-(o-tolyloxy)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; water / 6 h / 20 °C

2: dichloromethane / 3 h / 20 °C

3: sodium methylate / ethanol / 1.5 h / 150 °C / Microwave irradiation

With sodium methylate; sodium hydroxide; In methanol; ethanol; dichloromethane; water;